تقرير
Causally-interpretable meta-analysis: clearly-defined causal effects and two case studies
| العنوان: | Causally-interpretable meta-analysis: clearly-defined causal effects and two case studies |
|---|---|
| المؤلفون: | Rott, Kollin W., Bronfort, Gert, Chu, Haitao, Huling, Jared D., Leininger, Brent, Murad, Mohammad Hassan, Wang, Zhen, Hodges, James S. |
| سنة النشر: | 2023 |
| المجموعة: | Statistics |
| مصطلحات موضوعية: | Statistics - Methodology, Statistics - Applications |
| الوصف: | Meta-analysis is commonly used to combine results from multiple clinical trials, but traditional meta-analysis methods do not refer explicitly to a population of individuals to whom the results apply and it is not clear how to use their results to assess a treatment's effect for a population of interest. We describe recently-introduced causally-interpretable meta-analysis methods and apply their treatment effect estimators to two individual-participant data sets. These estimators transport estimated treatment effects from studies in the meta-analysis to a specified target population using individuals' potentially effect-modifying covariates. We consider different regression and weighting methods within this approach and compare the results to traditional aggregated-data meta-analysis methods. In our applications, certain versions of the causally-interpretable methods performed somewhat better than the traditional methods, but the latter generally did well. The causally-interpretable methods offer the most promise when covariates modify treatment effects and our results suggest that traditional methods work well when there is little effect heterogeneity. The causally-interpretable approach gives meta-analysis an appealing theoretical framework by relating an estimator directly to a specific population and lays a solid foundation for future developments. Comment: 31 pages, 2 figures Submitted to Research Synthesis Methods |
| نوع الوثيقة: | Working Paper |
| URL الوصول: | http://arxiv.org/abs/2302.07840 |
| رقم الأكسشن: | edsarx.2302.07840 |
| قاعدة البيانات: | arXiv |
| الوصف غير متاح. |