The Sand Hypoplastic (SH) constitutive law by von Wolffersdorff (1996) is a interesting hypoplastic model for soil mechanics. This model includes eight parameters, usually calibrated using the oedometric (OE) and the drained isotropically consolidated triaxial tests (CD). However, previous studies show that the SH model calibration in the CD test has conflicting requirements in predicting the evolution of stresses and strains. In this work, we study the SH model calibration over a wide range of testing conditions using 12 OE and 25 CD tests by Wichtmann and Triantafyllidis (2016) on the Karlsruhe sands. The parameter space is extensively explored via Genetic Algorithm Optimization (GA) using the recently developed open-source software GA-cal (available at \url{https://github.com/FraJoMen/GA-cal}). This exploration allowed us to study the SH model's predictive limits and to identify, using a multi-objective analysis, the main parameters governing the compromise between the accurate prediction of stresses versus strain in the CD tests.