Identifying TBI Physiological States by Clustering Multivariate Clinical Time-Series Data

التفاصيل البيبلوغرافية
العنوان: Identifying TBI Physiological States by Clustering Multivariate Clinical Time-Series Data
المؤلفون: Ghaderi, Hamid, Foreman, Brandon, Nayebi, Amin, Tipirneni, Sindhu, Reddy, Chandan K., Subbian, Vignesh
المصدر: AMIA Annu Symp Proc. 2024 Jan 11;2023:379-388
سنة النشر: 2023
المجموعة: Computer Science
مصطلحات موضوعية: Computer Science - Machine Learning, Computer Science - Artificial Intelligence, Electrical Engineering and Systems Science - Signal Processing
الوصف: Determining clinically relevant physiological states from multivariate time series data with missing values is essential for providing appropriate treatment for acute conditions such as Traumatic Brain Injury (TBI), respiratory failure, and heart failure. Utilizing non-temporal clustering or data imputation and aggregation techniques may lead to loss of valuable information and biased analyses. In our study, we apply the SLAC-Time algorithm, an innovative self-supervision-based approach that maintains data integrity by avoiding imputation or aggregation, offering a more useful representation of acute patient states. By using SLAC-Time to cluster data in a large research dataset, we identified three distinct TBI physiological states and their specific feature profiles. We employed various clustering evaluation metrics and incorporated input from a clinical domain expert to validate and interpret the identified physiological states. Further, we discovered how specific clinical events and interventions can influence patient states and state transitions.
Comment: 10 pages, 7 figures, 2 tables
نوع الوثيقة: Working Paper
URL الوصول: http://arxiv.org/abs/2303.13024
رقم الأكسشن: edsarx.2303.13024
قاعدة البيانات: arXiv