Interpretable Survival Analysis for Heart Failure Risk Prediction

التفاصيل البيبلوغرافية
العنوان: Interpretable Survival Analysis for Heart Failure Risk Prediction
المؤلفون: Van Ness, Mike, Bosschieter, Tomas, Din, Natasha, Ambrosy, Andrew, Sandhu, Alexander, Udell, Madeleine
سنة النشر: 2023
المجموعة: Computer Science
Statistics
مصطلحات موضوعية: Computer Science - Machine Learning, Statistics - Machine Learning
الوصف: Survival analysis, or time-to-event analysis, is an important and widespread problem in healthcare research. Medical research has traditionally relied on Cox models for survival analysis, due to their simplicity and interpretability. Cox models assume a log-linear hazard function as well as proportional hazards over time, and can perform poorly when these assumptions fail. Newer survival models based on machine learning avoid these assumptions and offer improved accuracy, yet sometimes at the expense of model interpretability, which is vital for clinical use. We propose a novel survival analysis pipeline that is both interpretable and competitive with state-of-the-art survival models. Specifically, we use an improved version of survival stacking to transform a survival analysis problem to a classification problem, ControlBurn to perform feature selection, and Explainable Boosting Machines to generate interpretable predictions. To evaluate our pipeline, we predict risk of heart failure using a large-scale EHR database. Our pipeline achieves state-of-the-art performance and provides interesting and novel insights about risk factors for heart failure.
نوع الوثيقة: Working Paper
URL الوصول: http://arxiv.org/abs/2310.15472
رقم الأكسشن: edsarx.2310.15472
قاعدة البيانات: arXiv