تقرير
A necessary condition for non-monotonic dose response, with an application to a kinetic proofreading model -- Extended version
| العنوان: | A necessary condition for non-monotonic dose response, with an application to a kinetic proofreading model -- Extended version |
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| المؤلفون: | Yu, Polly Y., Sontag, Eduardo D. |
| سنة النشر: | 2024 |
| المجموعة: | Mathematics Quantitative Biology |
| مصطلحات موضوعية: | Quantitative Biology - Molecular Networks, Mathematics - Optimization and Control |
| الوصف: | Steady state non-monotonic ("biphasic") dose responses are often observed in experimental biology, which raises the control-theoretic question of identifying which possible mechanisms might underlie such behaviors. It is well known that the presence of an incoherent feedforward loop (IFFL) in a network may give rise to a non-monotonic response. It has been conjectured that this condition is also necessary, i.e. that a non-monotonic response implies the existence of an IFFL. In this paper, we show that this conjecture is false, and in the process prove a weaker version: that either an IFFL must exist or both a positive loop and a negative feedback loop must exist. Towards this aim, we give necessary and sufficient conditions for when minors of a symbolic matrix have mixed signs. Finally, we study in full generality when a model of immune T-cell activation could exhibit a steady state non-monotonic dose response. Comment: Appendix included |
| نوع الوثيقة: | Working Paper |
| URL الوصول: | http://arxiv.org/abs/2403.13862 |
| رقم الأكسشن: | edsarx.2403.13862 |
| قاعدة البيانات: | arXiv |
| الوصف غير متاح. |