The widespread use of Artificial Intelligence-based tools in the healthcare sector raises many ethical and legal problems, one of the main reasons being their black-box nature and therefore the seemingly opacity and inscrutability of their characteristics and decision-making process. Literature extensively discusses how this can lead to phenomena of over-reliance and under-reliance, ultimately limiting the adoption of AI. We addressed these issues by building a theoretical framework based on three concepts: Feature Importance, Counterexample Explanations, and Similar-Case Explanations. Grounded in the literature, the model was deployed within a case study in which, using a participatory design approach, we designed and developed a high-fidelity prototype. Through the co-design and development of the prototype and the underlying model, we advanced the knowledge on how to design AI-based systems for enabling complementarity in the decision-making process in the healthcare domain. Our work aims at contributing to the current discourse on designing AI systems to support clinicians' decision-making processes.
