The holographic Schwinger effect is investigated in systems with Nf = 0, Nf = 2, and Nf = 2+1 using the Einstein-Maxwell-Dilaton (EMD) model, incorporating equation of state and baryon number susceptibility information from lattice QCD. It is found that the critical electric field is smallest for Nf = 0, indicating that the Schwinger effect is more likely to occur than in systems with Nf = 2 and Nf = 2+ 1. The critical electric field decreases with increasing chemical potential and temperature across all systems. Additionally, potential analysis confirms that the maximum total potential energy increases with the number of flavors, suggesting that existing particles may reduce the probability of particle pair production.
