تقرير
Heterogeneous model for superdiffusive movement of dense-core vesicles in C. elegans
| العنوان: | Heterogeneous model for superdiffusive movement of dense-core vesicles in C. elegans |
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| المؤلفون: | Gavrilova, Anna, Korabel, Nickolay, Allan, Victoria J., Fedotov, Sergei |
| سنة النشر: | 2024 |
| المجموعة: | Quantitative Biology |
| مصطلحات موضوعية: | Quantitative Biology - Subcellular Processes |
| الوصف: | Transport of dense core vesicles (DCVs) in neurons is crucial for distributing molecules like neuropeptides and growth factors. We studied the experimental trajectories of dynein-driven directed movement of DCVs in the ALA neuron C. elegans over a duration of up to 6 seconds. We analysed the DCV movement in three strains of C. elegans: 1) with normal kinesin-1 function, 2) with reduced function in kinesin light chain 2 (KLC-2), and 3) a null mutation in kinesin light chain 1 (KLC-1). We find that DCVs move superdiffusively with displacement variance $var(x) \sim t^2$ in all three strains with low reversal rates and frequent immobilization of DCVs. The distribution of DCV displacements fits a beta-binomial distribution with the mean and the variance following linear and quadratic growth patterns, respectively. We propose a simple heterogeneous random walk model to explain the observed superdiffusive retrograde transport behaviour of DCV movement. This model involves a random probability with the beta density for a DCV to resume its movement or remain in the same position. Comment: 9 pages, 5 figures |
| نوع الوثيقة: | Working Paper |
| URL الوصول: | http://arxiv.org/abs/2407.18237 |
| رقم الأكسشن: | edsarx.2407.18237 |
| قاعدة البيانات: | arXiv |
| الوصف غير متاح. |