دورية أكاديمية
HBA-DEALS: accurate and simultaneous identification of differential expression and splicing using hierarchical Bayesian analysis
| العنوان: | HBA-DEALS: accurate and simultaneous identification of differential expression and splicing using hierarchical Bayesian analysis |
|---|---|
| المؤلفون: | Guy Karlebach, Peter Hansen, Diogo FT Veiga, Robin Steinhaus, Daniel Danis, Sheng Li, Olga Anczukow, Peter N Robinson |
| المصدر: | Genome Biology, Vol 21, Iss 1, Pp 1-20 (2020) |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Biology (General) LCC:Genetics |
| مصطلحات موضوعية: | Differential expression, Alternative splicing, Transcription, Biology (General), QH301-705.5, Genetics, QH426-470 |
| الوصف: | Abstract We present Hierarchical Bayesian Analysis of Differential Expression and ALternative Splicing (HBA-DEALS), which simultaneously characterizes differential expression and splicing in cohorts. HBA-DEALS attains state of the art or better performance for both expression and splicing and allows genes to be characterized as having differential gene expression, differential alternative splicing, both, or neither. HBA-DEALS analysis of GTEx data demonstrated sets of genes that show predominant DGE or DAST across multiple tissue types. These sets have pervasive differences with respect to gene structure, function, membership in protein complexes, and promoter architecture. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1474-760X |
| Relation: | http://link.springer.com/article/10.1186/s13059-020-02072-6; https://doaj.org/toc/1474-760X |
| DOI: | 10.1186/s13059-020-02072-6 |
| URL الوصول: | https://doaj.org/article/0007505bb5ac496f9757719472ccbfeb |
| رقم الأكسشن: | edsdoj.0007505bb5ac496f9757719472ccbfeb |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1474760X |
|---|---|
| DOI: | 10.1186/s13059-020-02072-6 |