دورية أكاديمية
Multiple factor analysis of metachronous upper urinary tract transitional cell carcinoma after radical cystectomy
| العنوان: | Multiple factor analysis of metachronous upper urinary tract transitional cell carcinoma after radical cystectomy |
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| المؤلفون: | P. Wang, J.D. Luo, W.F. Wu, S. Wang, S.L. Cai, B.H. Shen, S.F. Shi, K.X. Wei, Z.G. Zhang, Z.D. Chen |
| المصدر: | Brazilian Journal of Medical and Biological Research, Vol 40, Iss 7, Pp 979-984 (2007) |
| بيانات النشر: | Associação Brasileira de Divulgação Científica, 2007. |
| سنة النشر: | 2007 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Bladder neoplasm, Transitional cell carcinoma, Upper urinary tract, Radical cystectomy, Prognosis, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Transitional cell carcinoma (TCC) of the urothelium is often multifocal and subsequent tumors may occur anywhere in the urinary tract after the treatment of a primary carcinoma. Patients initially presenting a bladder cancer are at significant risk of developing metachronous tumors in the upper urinary tract (UUT). We evaluated the prognostic factors of primary invasive bladder cancer that may predict a metachronous UUT TCC after radical cystectomy. The records of 476 patients who underwent radical cystectomy for primary invasive bladder TCC from 1989 to 2001 were reviewed retrospectively. The prognostic factors of UUT TCC were determined by multivariate analysis using the COX proportional hazards regression model. Kaplan-Meier analysis was also used to assess the variable incidence of UUT TCC according to different risk factors. Twenty-two patients (4.6%). developed metachronous UUT TCC. Multiplicity, prostatic urethral involvement by the bladder cancer and the associated carcinoma in situ (CIS) were significant and independent factors affecting the occurrence of metachronous UUT TCC (P = 0.0425, 0.0082, and 0.0006, respectively). These results were supported, to some extent, by analysis of the UUT TCC disease-free rate by the Kaplan-Meier method, whereby patients with prostatic urethral involvement or with associated CIS demonstrated a significantly lower metachronous UUT TCC disease-free rate than patients without prostatic urethral involvement or without associated CIS (log-rank test, P = 0.0116 and 0.0075, respectively). Multiple tumors, prostatic urethral involvement and associated CIS were risk factors for metachronous UUT TCC, a conclusion that may be useful for designing follow-up strategies for primary invasive bladder cancer after radical cystectomy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0100-879X 1414-431X |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000700013; https://doaj.org/toc/0100-879X; https://doaj.org/toc/1414-431X |
| URL الوصول: | https://doaj.org/article/00809185c2d74845a9101193f84d1bc9 |
| رقم الأكسشن: | edsdoj.00809185c2d74845a9101193f84d1bc9 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 0100879X 1414431X |
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