دورية أكاديمية
LncRNA KCNQ1OT1 promotes the metastasis of ovarian cancer by increasing the methylation of EIF2B5 promoter
| العنوان: | LncRNA KCNQ1OT1 promotes the metastasis of ovarian cancer by increasing the methylation of EIF2B5 promoter |
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| المؤلفون: | Si-Li He, Ya-Ling Chen, Qi-Hua Chen, Qi Tian, Shui-Jing Yi |
| المصدر: | Molecular Medicine, Vol 28, Iss 1, Pp 1-12 (2022) |
| بيانات النشر: | BMC, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Therapeutics. Pharmacology LCC:Biochemistry |
| مصطلحات موضوعية: | Ovarian cancer, lncRNA KCNQ1OT1, EIF2B5, Methylation, Proliferation, Metastasis, Therapeutics. Pharmacology, RM1-950, Biochemistry, QD415-436 |
| الوصف: | Highlights 1. LncRNA KCNQ1OT1 is upregulated, while EIF2B5 is downregulated in OC tissues and cells. 2. Knockdown of KCNQ1OT1 represses OC cell proliferation and metastasis. 3. KCNQ1OT1 decreases EIF2B5 expression by recruiting DNA methyltransferases into EIF2B5 promoter, thereby promoting OC progression. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1076-1551 1528-3658 |
| Relation: | https://doaj.org/toc/1076-1551; https://doaj.org/toc/1528-3658 |
| DOI: | 10.1186/s10020-022-00521-5 |
| URL الوصول: | https://doaj.org/article/00a070ec54ae4a71a62c7fcfedc31fc0 |
| رقم الأكسشن: | edsdoj.00a070ec54ae4a71a62c7fcfedc31fc0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 10761551 15283658 |
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| DOI: | 10.1186/s10020-022-00521-5 |