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Multi-ancestry meta-analysis of host genetic susceptibility to tuberculosis identifies shared genetic architecture

التفاصيل البيبلوغرافية
العنوان: Multi-ancestry meta-analysis of host genetic susceptibility to tuberculosis identifies shared genetic architecture
المؤلفون: Haiko Schurz, Vivek Naranbhai, Tom A Yates, James J Gilchrist, Tom Parks, Peter J Dodd, Marlo Möller, Eileen G Hoal, Andrew P Morris, Adrian VS Hill, International Tuberculosis Host Genetics Consortium
المصدر: eLife, Vol 13 (2024)
بيانات النشر: eLife Sciences Publications Ltd, 2024.
سنة النشر: 2024
المجموعة: LCC:Medicine
LCC:Science
LCC:Biology (General)
مصطلحات موضوعية: tuberculosis, GWAS, multi-ancestry, meta-analysis, HLA, Medicine, Science, Biology (General), QH301-705.5
الوصف: The heritability of susceptibility to tuberculosis (TB) disease has been well recognized. Over 100 genes have been studied as candidates for TB susceptibility, and several variants were identified by genome-wide association studies (GWAS), but few replicate. We established the International Tuberculosis Host Genetics Consortium to perform a multi-ancestry meta-analysis of GWAS, including 14,153 cases and 19,536 controls of African, Asian, and European ancestry. Our analyses demonstrate a substantial degree of heritability (pooled polygenic h2 = 26.3%, 95% CI 23.7–29.0%) for susceptibility to TB that is shared across ancestries, highlighting an important host genetic influence on disease. We identified one global host genetic correlate for TB at genome-wide significance (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2050-084X
Relation: https://elifesciences.org/articles/84394; https://doaj.org/toc/2050-084X
DOI: 10.7554/eLife.84394
URL الوصول: https://doaj.org/article/00c3c9bd8aaa466cb16976111e168c78
رقم الأكسشن: edsdoj.00c3c9bd8aaa466cb16976111e168c78
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2050084X
DOI:10.7554/eLife.84394