دورية أكاديمية
The Role of Neuropeptide B and Its Receptors in Controlling Appetite, Metabolism, and Energy Homeostasis
العنوان: | The Role of Neuropeptide B and Its Receptors in Controlling Appetite, Metabolism, and Energy Homeostasis |
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المؤلفون: | Tatiana Wojciechowicz, Maria Billert, Mariami Jasaszwili, Mathias Z. Strowski, Krzysztof W. Nowak, Marek Skrzypski |
المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 12, p 6632 (2021) |
بيانات النشر: | MDPI AG, 2021. |
سنة النشر: | 2021 |
المجموعة: | LCC:Biology (General) LCC:Chemistry |
مصطلحات موضوعية: | appetite, neuropeptide B, NPBWR1, NPRBWR2, metabolism, energy homeostasis, Biology (General), QH301-705.5, Chemistry, QD1-999 |
الوصف: | Neuropeptide B (NPB) is a peptide hormone that was initially described in 2002. In humans, the biological effects of NPB depend on the activation of two G protein-coupled receptors, NPBWR1 (GPR7) and NPBWR2 (GPR8), and, in rodents, NPBWR1. NPB and its receptors are expressed in the central nervous system (CNS) and in peripheral tissues. NPB is also present in the circulation. In the CNS, NPB modulates appetite, reproduction, pain, anxiety, and emotions. In the peripheral tissues, NPB controls secretion of adrenal hormones, pancreatic beta cells, and various functions of adipose tissue. Experimental downregulation of either NPB or NPBWR1 leads to adiposity. Here, we review the literature with regard to NPB-dependent control of metabolism and energy homeostasis. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1422-0067 1661-6596 |
Relation: | https://www.mdpi.com/1422-0067/22/12/6632; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
DOI: | 10.3390/ijms22126632 |
URL الوصول: | https://doaj.org/article/011111ea18cd427099013adc9c49bc27 |
رقم الأكسشن: | edsdoj.011111ea18cd427099013adc9c49bc27 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14220067 16616596 |
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DOI: | 10.3390/ijms22126632 |