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The Role of Neuropeptide B and Its Receptors in Controlling Appetite, Metabolism, and Energy Homeostasis

التفاصيل البيبلوغرافية
العنوان: The Role of Neuropeptide B and Its Receptors in Controlling Appetite, Metabolism, and Energy Homeostasis
المؤلفون: Tatiana Wojciechowicz, Maria Billert, Mariami Jasaszwili, Mathias Z. Strowski, Krzysztof W. Nowak, Marek Skrzypski
المصدر: International Journal of Molecular Sciences, Vol 22, Iss 12, p 6632 (2021)
بيانات النشر: MDPI AG, 2021.
سنة النشر: 2021
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: appetite, neuropeptide B, NPBWR1, NPRBWR2, metabolism, energy homeostasis, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Neuropeptide B (NPB) is a peptide hormone that was initially described in 2002. In humans, the biological effects of NPB depend on the activation of two G protein-coupled receptors, NPBWR1 (GPR7) and NPBWR2 (GPR8), and, in rodents, NPBWR1. NPB and its receptors are expressed in the central nervous system (CNS) and in peripheral tissues. NPB is also present in the circulation. In the CNS, NPB modulates appetite, reproduction, pain, anxiety, and emotions. In the peripheral tissues, NPB controls secretion of adrenal hormones, pancreatic beta cells, and various functions of adipose tissue. Experimental downregulation of either NPB or NPBWR1 leads to adiposity. Here, we review the literature with regard to NPB-dependent control of metabolism and energy homeostasis.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
1661-6596
Relation: https://www.mdpi.com/1422-0067/22/12/6632; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms22126632
URL الوصول: https://doaj.org/article/011111ea18cd427099013adc9c49bc27
رقم الأكسشن: edsdoj.011111ea18cd427099013adc9c49bc27
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
16616596
DOI:10.3390/ijms22126632