دورية أكاديمية
Pharmacognostic characterization, wound healing and toxicity assessment of the stem bark of Xylia evansii Hutch (Leguminosae)
| العنوان: | Pharmacognostic characterization, wound healing and toxicity assessment of the stem bark of Xylia evansii Hutch (Leguminosae) |
|---|---|
| المؤلفون: | Lord Gyimah, Evelyn Asante-Kwatia, Silas Adjei, Frederick Akuffo Owusu, Fanny Darko, Ernest Tabiri, Abraham Yeboah Mensah |
| المصدر: | Heliyon, Vol 9, Iss 11, Pp e21692- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Xylia evansii, Wound, Safety, Histopathology, Microscopy, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Xylia evansii is widely used in traditional medicine to stop bleeding gums and treat wounds. This study was undertaken to assess the wound healing activity and toxicity profile of the stem bark methanol extract of X. evansii (XES). Wound healing activity was determined by the dermal excision model in rats. The free radical scavenging capacity, antioxidant activity, total phenolic and flavonoid contents were evaluated by the 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging, total antioxidant capacity (TAC), aluminum chloride colorimetric and Folin Ciocalteu methods respectively. Acute and sub-acute oral toxicity assessment was performed following the Organization for Economic Co-operation and Development guidelines. Significant (p 5000 mg/kg. In sub-acute toxicity, 28 days treatment with XES (250, 500, 1000 mg/kg body weight) did not result in any significant (p > 0.05) change in the body weight or weight of the heart, lung, spleen, liver and kidneys. The haematological and biochemical profiles of XES-treated rats were not significantly (p > 0.05) affected after 4-weeks treatment with XES, except for platelet count which increased significantly (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844023089004; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2023.e21692 |
| URL الوصول: | https://doaj.org/article/014fa17a8343409d835085b2bf687361 |
| رقم الأكسشن: | edsdoj.014fa17a8343409d835085b2bf687361 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
|---|---|
| DOI: | 10.1016/j.heliyon.2023.e21692 |