دورية أكاديمية
A role for p53 in telomere protection
| العنوان: | A role for p53 in telomere protection |
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| المؤلفون: | Stephen Tutton, Paul M. Lieberman |
| المصدر: | Molecular & Cellular Oncology, Vol 4, Iss 6 (2017) |
| بيانات النشر: | Taylor & Francis Group, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | chromatin, dna-damage, erna, telomere, terra, tp53, yh2ax, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Telomeres cap the ends of chromosomes and are crucial for genome stability. The p53 protein (TP53) is a vital tumor suppressor, activating the transcription of numerous genes in response to cell stress. We reported that direct binding of p53 at human subtelomeres corresponds with local transcription activation and enhanced telomere stability in the presence of DNA damage. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2372-3556 23723556 |
| Relation: | https://doaj.org/toc/2372-3556 |
| DOI: | 10.1080/23723556.2016.1143078 |
| URL الوصول: | https://doaj.org/article/d0165b5f127a4c41872d4d626f2ba540 |
| رقم الأكسشن: | edsdoj.0165b5f127a4c41872d4d626f2ba540 |
| قاعدة البيانات: | Directory of Open Access Journals |
PDF full text from Publisher | تدمد: | 23723556 |
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| DOI: | 10.1080/23723556.2016.1143078 |