التفاصيل البيبلوغرافية
العنوان:
The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development
المؤلفون:
Stefanie Wojciech , Raise Ahmad , Zakia Belaid-Choucair , Anne-Sophie Journé , Sarah Gallet , Julie Dam , Avais Daulat , Delphine Ndiaye-Lobry , Olivier Lahuna , Angeliki Karamitri , Jean-Luc Guillaume , Marcio Do Cruzeiro , François Guillonneau , Anastasia Saade , Nathalie Clément , Thomas Courivaud , Nawel Kaabi , Kenjiro Tadagaki , Philippe Delagrange , Vincent Prévot , Olivier Hermine , Céline Prunier , Ralf Jockers
المصدر:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
بيانات النشر:
Nature Portfolio, 2018.
سنة النشر:
2018
المجموعة:
LCC:Science
مصطلحات موضوعية:
Science
الوصف:
Transforming growth factor-β (TGFβ) regulates many cellular processes. Here the authors show that the orphan G-protein coupled receptor GPR50 can activate the TGFβ receptor I, in the absence of TGFβ, by stabilizing its active conformation and show antitumor activity in a mouse model of breast cancer.
نوع الوثيقة:
article
وصف الملف:
electronic resource
اللغة:
English
تدمد:
2041-1723
Relation:
https://doaj.org/toc/2041-1723
DOI:
10.1038/s41467-018-03609-x
URL الوصول:
https://doaj.org/article/ee01b8e19b6d47e3a5db8a61ae00a911
رقم الأكسشن:
edsdoj.01b8e19b6d47e3a5db8a61ae00a911
قاعدة البيانات:
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