دورية أكاديمية
Clinical prediction nomogram for steroid-induced ocular hypertension risk in patients with intravitreal dexamethasone implant
| العنوان: | Clinical prediction nomogram for steroid-induced ocular hypertension risk in patients with intravitreal dexamethasone implant |
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| المؤلفون: | Won Jeong Cho, Hye Jung Shin, Min Kim, Hyoung Won Bae, Chan Yun Kim, Wungrak Choi |
| المصدر: | Heliyon, Vol 10, Iss 14, Pp e34635- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Steroid-induced ocular hypertension, Intraocular pressure, Trabecular meshwork height, Anterior segment optical coherence tomography, Intravitreal dexamethasone injection, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Background: Recognizing the risk factors and understanding the mechanisms underlying steroid-induced ocular hypertension (SIOH) are vital to prevent potent vision loss and ensure the safety and effectiveness of dexamethasone (DEX) injections. The study aimed to develop a novel nomogram for predicting the risk of SIOH and determining safety zones for steroid injections. Methods: This single-center, retrospective, case-control study included a total of 154 eyes with available measured axial length that had undergone AS-OCT and DEX implantation at the Yonsei University Health System. The eyes were categorized into the SIOH (n = 39) and post-steroid normal IOP (n = 115) groups. We measured intraocular pressure (IOP) for all eyes prior to DEX implantation, at 1 week post-implantation, and at 1, 2, 3, 6, and 12 months thereafter. We used AS-OCT to analyze the trabecular meshwork (TM) height and ocular parameters. Results: The predictive nomogram, including TM height, yielded an AUC of 0.807 (95 % confidence interval [CI], 0.737–0.877) and demonstrated significantly higher predictive accuracy than that of previous nomograms, which did not consider TM height and had an AUC of 0.644 (95 % CI, 0.543–0.745) (p = 0.031). The calibration plot demonstrated a strong predictive accuracy for a predicted value of approximately 0.4. We established cutoff values to ensure different levels of sensitivity and specificity within the safety zone following DEX implantation. Conclusion: Our improved nomogram incorporating TM height as a newly identified risk factor, established a safety threshold for intravitreal DEX implantation, helping identify safe individuals from those who require caution. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844024106664; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2024.e34635 |
| URL الوصول: | https://doaj.org/article/02284110ee2547349d8005b46151681f |
| رقم الأكسشن: | edsdoj.02284110ee2547349d8005b46151681f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2024.e34635 |