دورية أكاديمية
Disruption of PAK3 Signaling in Social Interaction Induced cFos Positive Cells Impairs Social Recognition Memory
| العنوان: | Disruption of PAK3 Signaling in Social Interaction Induced cFos Positive Cells Impairs Social Recognition Memory |
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| المؤلفون: | Susan Zhou, Zhengping Jia |
| المصدر: | Cells, Vol 10, Iss 11, p 3010 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Cytology |
| مصطلحات موضوعية: | p21-activated kinase, tetracycline-inducible system, cFos positive cells, social recognition memory, Cytology, QH573-671 |
| الوصف: | P21-activated kinase 3 (PAK3) gene mutations are linked to several neurodevelopmental disorders, but the underlying mechanisms remain unclear. In this study, we used a tetracycline-inducible system to control the expression of a mutant PAK3 (mPAK3) protein in immediate early gene, namely cFos, positive cells to disrupt PAK signaling, specifically in cells activated by social interaction in transgenic mice. We show that the expression of mPAK3-GFP proteins was in cFos-expressing excitatory and inhibitory neurons in various brain regions, such as the cortex and hippocampus, commonly activated during learning and memory. Basal expression of mPAK3-GFP proteins in cFos-positive cells resulted in social recognition memory deficits in the three-chamber social interaction test, without affecting locomotor activity or other forms of memory. The social memory deficit was rescued by doxycycline to halt the mPAK3-GFP transgene expression. In addition, we show that the expression of mPAK3-GFP proteins in a subset of cFos-positive cells, induced by an antecedent short social interaction, termed social pairing, was sufficient to impair social recognition memory. These results indicate that normal PAK signaling in cFos-positive cells activated during social interaction is critical for social memory. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 10113010 2073-4409 |
| Relation: | https://www.mdpi.com/2073-4409/10/11/3010; https://doaj.org/toc/2073-4409 |
| DOI: | 10.3390/cells10113010 |
| URL الوصول: | https://doaj.org/article/0285c174aed64877b54cc913a28d88c5 |
| رقم الأكسشن: | edsdoj.0285c174aed64877b54cc913a28d88c5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10113010 20734409 |
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| DOI: | 10.3390/cells10113010 |