دورية أكاديمية
Cordyceps militaris Fruit Body Extract Decreases Testosterone Catabolism and Testosterone-Stimulated Prostate Hypertrophy
| العنوان: | Cordyceps militaris Fruit Body Extract Decreases Testosterone Catabolism and Testosterone-Stimulated Prostate Hypertrophy |
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| المؤلفون: | Kazuya Kusama, Mayuko Miyagawa, Koichiro Ota, Naoko Kuwabara, Kaori Saeki, Yuki Ohnishi, Yasuhiro Kumaki, Tomoyasu Aizawa, Toyokazu Nakasone, Shigemi Okamatsu, Hiroaki Miyaoka, Kazuhiro Tamura |
| المصدر: | Nutrients, Vol 13, Iss 1, p 50 (2020) |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Nutrition. Foods and food supply |
| مصطلحات موضوعية: | Cordyceps militaris, testosterone, late-onset hypogonadism (LOH), prostate, benign prostate hyperplasia (BPH), Nutrition. Foods and food supply, TX341-641 |
| الوصف: | The androgens testosterone and dihydrotestosterone (DHT) are essential for a variety of systemic functions in mature males. Alteration of these hormones results in late-onset hypogonadism (LOH) and benign prostate hyperplasia (BPH). The fruit bodies of fungi of the genus Cordyceps have been regarded as folk medicine or health food with tonic and antifatigue effects. The extract from the fruit body of Cordyceps militaris parasitizing Samia cynthia ricini (CM) was evaluated as a novel-candidate natural product for ameliorating male andropause symptoms. To explore the effects of CM on LOH and BPH, CM was applied to rat models and cultured testicular cells and prostate cells. The concentrations of androgens in the serum and culture media were determined by ELISA. Expression of steroidogenic enzymes and androgen-related genes was evaluated by qPCR, and prostatic cell proliferation was assessed with the cell-viability assay. CM maintained the serum levels of testosterone and DHT, but inhibited testosterone-induced prostate hypertrophy. CM also increased the secretion of testosterone and DHT by primary testicular cells, with no changes in the mRNA expression of steroidogenic enzymes, but decreased the growth of prostatic cell lines. Our data suggest that CM could improve both LOH and BPH in males. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 13010050 2072-6643 |
| Relation: | https://www.mdpi.com/2072-6643/13/1/50; https://doaj.org/toc/2072-6643 |
| DOI: | 10.3390/nu13010050 |
| URL الوصول: | https://doaj.org/article/d02a9d0eb65b466290813225d9b3564a |
| رقم الأكسشن: | edsdoj.02a9d0eb65b466290813225d9b3564a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13010050 20726643 |
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| DOI: | 10.3390/nu13010050 |