دورية أكاديمية
أعرض في EDS

Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial.

التفاصيل البيبلوغرافية
العنوان: Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial.
المؤلفون: Kim M Huffman, Leanne M Redman, Lawrence R Landerman, Carl F Pieper, Robert D Stevens, Michael J Muehlbauer, Brett R Wenner, James R Bain, Virginia B Kraus, Christopher B Newgard, Eric Ravussin, William E Kraus
المصدر: PLoS ONE, Vol 7, Iss 4, p e28190 (2012)
بيانات النشر: Public Library of Science (PLoS), 2012.
سنة النشر: 2012
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: To determine if caloric restriction (CR) would cause changes in plasma metabolic intermediates in response to a mixed meal, suggestive of changes in the capacity to adapt fuel oxidation to fuel availability or metabolic flexibility, and to determine how any such changes relate to insulin sensitivity (S(I)).Forty-six volunteers were randomized to a weight maintenance diet (Control), 25% CR, or 12.5% CR plus 12.5% energy deficit from structured aerobic exercise (CR+EX), or a liquid calorie diet (890 kcal/d until 15% reduction in body weight)for six months. Fasting and postprandial plasma samples were obtained at baseline, three, and six months. A targeted mass spectrometry-based platform was used to measure concentrations of individual free fatty acids (FFA), amino acids (AA), and acylcarnitines (AC). S(I) was measured with an intravenous glucose tolerance test.Over three and six months, there were significantly larger differences in fasting-to-postprandial (FPP) concentrations of medium and long chain AC (byproducts of FA oxidation) in the CR relative to Control and a tendency for the same in CR+EX (CR-3 month P = 0.02; CR-6 month P = 0.002; CR+EX-3 month P = 0.09; CR+EX-6 month P = 0.08). After three months of CR, there was a trend towards a larger difference in FPP FFA concentrations (P = 0.07; CR-3 month P = 0.08). Time-varying differences in FPP concentrations of AC and AA were independently related to time-varying S(I) (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3327714?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0028190
URL الوصول: https://doaj.org/article/02e6b7fb4190457b8721f0b5c8321b7b
رقم الأكسشن: edsdoj.02e6b7fb4190457b8721f0b5c8321b7b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0028190