دورية أكاديمية
Lack of Association of Multidrug Resistance Gene-1 Polymorphisms with Treatment Outcome in Chronic Myeloid Leukemia Patients Treated with Imatinib
| العنوان: | Lack of Association of Multidrug Resistance Gene-1 Polymorphisms with Treatment Outcome in Chronic Myeloid Leukemia Patients Treated with Imatinib |
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| المؤلفون: | Yaya Kassogue, Hind Dehbi, Meryem Quachouh, Asma Quessar, Said Benchekroun, Sellama Nadifi |
| المصدر: | Middle East Journal of Cancer, Vol 6, Iss 4, Pp 229-235 (2015) |
| بيانات النشر: | Shiraz University of Medical Sciences, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | MDR1 polymorphisms, Chronic myeloid leukemia, Imatinib mesylate, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Background: Despite the impressive results obtained with imatinib, inadequate response or resistance are observed in certain patients. It is known that imatinib is a substrate of a multidrug resistance gene (MDR1). Thus, interindividual genetic differences linked to single nucleotide polymorphisms in MDR1 may influence the metabolism of imatinib. The present study has aimed to examine the impact of MDR1 polymorphisms on the hematologic and cytogenetic responses in 70 chronic myeloid leukemia patients who received imatinib. Methods: We used a polymerase chain reaction followed by restriction fragment length polymorphism to identify different profiles of 1236C>T, 2677G>T and 3435C>T in MDR1. Results: The distribution of the three SNPs in responders and poor responders did not show any particular trend (P>0.05). The T allele was slightly higher in responders, but not significantly regardless of the type of SNP (40.3% vs. 33.8% for 1236C>T; 25% vs. 14.7% for 2677G>T and 33.3% vs. 22% for 3435C>T). The dominant model showed a similar trend (P>0.05). Diplotypes composed by the T allele in different exons were frequent in responders. Haplotype analysis showed that 1236C-2677G-3435C was slightly higher in poor responders (60.02%) compared to responders (50.42%). However, 1236T-2677T-3435T was frequent in responders (16.98%) compared to poor responders (13.1%). Overall, none of the haplotypes were associated with IM response in our cohort (global haplotype association test, P=0.39). Conclusion: The identification of 1236C>T, 2677G>T and 3435C>T polymorphisms may not be advantageous to predict imatinib response for our chronic myeloid leukemia patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2008-6709 2008-6687 |
| Relation: | http://mejc.sums.ac.ir/index.php/mejc/article/view/269/228; https://doaj.org/toc/2008-6709; https://doaj.org/toc/2008-6687 |
| URL الوصول: | https://doaj.org/article/02f105ff2e6e463ba354b297cf979b43 |
| رقم الأكسشن: | edsdoj.02f105ff2e6e463ba354b297cf979b43 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20086709 20086687 |
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