دورية أكاديمية
The effect of N-stearoylethanolamine on plasma lipid composition in rats with experimental insulin resistance
| العنوان: | The effect of N-stearoylethanolamine on plasma lipid composition in rats with experimental insulin resistance |
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| المؤلفون: | O. V. Onopchenko, G. V. Kosiakova, V. M. Klimashevsky, N. M. Hula |
| المصدر: | The Ukrainian Biochemical Journal, Vol 87, Iss 1, Pp 46-54 (2015) |
| بيانات النشر: | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Biochemistry LCC:Medicine LCC:Biology (General) |
| مصطلحات موضوعية: | Biochemistry, QD415-436, Medicine, Biology (General), QH301-705.5 |
| الوصف: | A model of insulin resistance (IR), induced by prolonged high fat diet with high content of saturated fats was used to investigate the effect of N-stearoylethanolamine (NSE) on the composition of free fatty acids (FFA), plasma lipoprotein spectrum and content of proinflammatory cytokine TNFα in rats. The results of this work showed a rise in the content of monounsaturated fatty acids (18:1 n-9) and a reduction in the level of polyunsaturated fatty acids (20:4 n-6) in plasma of rats with experimental IR. These findings are accompanied by the increased TNFα production and significant changes in plasma lipoprotein profile of rats with the fat overload. Particularly, a decreased high-density lipoprotein (HDL) cholesterol level and increased low-density (LDL) and very low-density lipoprotein (VLDL) cholesterol level were detected. The NSE administration to obese rats with IR restored the content of mono- and polyunsaturated FFA, increased HDL cholesterol content and reduced LDL cholesterol level. In addition, the IR rats treated with NSE showed normalization in the serum TNFα level. Our results showed the restoration of plasma lipid profile under NSE administration in rats with obesity-induced IR. Considering the fact that plasma lipid composition displays the lipid metabolism in general, the NSE actions may play a significant role in the prevention of IR-associated complications. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2409-4943 2413-5003 |
| Relation: | http://ukrbiochemjournal.org/wp-content/uploads/2015/05/Onopchenko_1_15.pdf; https://doaj.org/toc/2409-4943; https://doaj.org/toc/2413-5003 |
| DOI: | 10.15407/ubj87.01.046 |
| URL الوصول: | https://doaj.org/article/0302d8a4c0a84c408eb2c28dae964da0 |
| رقم الأكسشن: | edsdoj.0302d8a4c0a84c408eb2c28dae964da0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24094943 24135003 |
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| DOI: | 10.15407/ubj87.01.046 |