دورية أكاديمية
IMMUNOLOGICAL IMBALANCE IN BREAST CANCER AND LUNG CANCER IN POSTMENOPAUSAL WOMEN
| العنوان: | IMMUNOLOGICAL IMBALANCE IN BREAST CANCER AND LUNG CANCER IN POSTMENOPAUSAL WOMEN |
|---|---|
| المؤلفون: | A. N. Glushkov, E. G. Polenok, L. A. Gordeeva, S. A. Mun, M. V. Kostyanko, A. V. Antonov, V. A. Titov, N. E. Verzhbitskaya, I. A. Vafin |
| المصدر: | Медицинская иммунология, Vol 20, Iss 6, Pp 927-934 (2018) |
| بيانات النشر: | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: | breast cancer, lung cancer, antibodies, benzo[a]pyrene, estradiol, progesterone, carcinogenesis, Immunologic diseases. Allergy, RC581-607 |
| الوصف: | Previous studies reported some associations between class A antibodies specific for benzo[a]pyrene (IgA-Bp), estradiol (IgA-Es) and progesterone (IgA-Pg) and breast cancer (BC) in women like as with lung cancer (LC) in men. It was suggested that IgA-Bp and IgA-Es may stimulate tumor initiation and promotion, whereas IgA-Pg may inhibit the in vivo human carcinogenesis.The purpose of this study was to identify the suggested associations of such immunological imbalance with BC and LC in postmenopausal women.The serum A-class antibodies specific to benzo[a]pyrene, estradiol and progesterone (IgA-Bp, IgA-Es, IgA- Pg) were studied in 335 healthy women, 824 breast cancer (BC) patients and 127 cases of lung cancer (LC) by means of non-competitive solid phase immunoassay. The following results were obtained: Increased ratio of IgA-Bp and IgA-Es amounts exceeding the IgA-Pg levels was associated with a higher risk of breast cancer (OR = 2.8 and 2.4 respectively, p < 0.0001), and higher risk of LC (OR = 2.9 and 2.8, respectively, p < 0.0001). Conversely, the OR values decreased to 0.3-0.4 for BC and LC if IgA-Pg levels were higher than IgA-Bp and IgA-Es levels (p < 0.0001). These findings confirm the hypothesis that IgA-Bp and IgA-Es are capable to stimulate, and IgA-Pg, to inhibit the BC and LC occurrence n postmenopausal women. The balance between IgA-Bp and IgA-Es, on the one hand, and IgA-Pg, on the other hand, is much more important than individual contents of these antibodies.In conclusion, the phenomenon of “immunological interference” is revealed, i.e., the mutual enhancement of IgA-Bp and IgA-Es effects, thus, probably, stimulating the initial and subsequent events of carcinogenesis initiation and promotion, with a weak anticancer effect of IgA-Pg, and by weakening the mutual procarcinogenic effects of IgA-Bp and IgA-Es by the marked effect of IgA-Pg. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 1563-0625 2313-741X |
| Relation: | https://www.mimmun.ru/mimmun/article/view/1681; https://doaj.org/toc/1563-0625; https://doaj.org/toc/2313-741X |
| DOI: | 10.15789/1563-0625-2018-6-927-934 |
| URL الوصول: | https://doaj.org/article/03459d37357d4e0285d4141d1617687e |
| رقم الأكسشن: | edsdoj.03459d37357d4e0285d4141d1617687e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15630625 2313741X |
|---|---|
| DOI: | 10.15789/1563-0625-2018-6-927-934 |