دورية أكاديمية
Anti-Hepatocellular Carcinoma Effects of the Chloroform Root Extract of Burm
| العنوان: | Anti-Hepatocellular Carcinoma Effects of the Chloroform Root Extract of Burm |
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| المؤلفون: | Peter Waziri BSc, MSc, PhD, Richard Auta BSc, MSc, PhD, Mustapha U Imam MBBS, MSc, PhD, Ben A Chindo BPharm, MSc, PhD, Zakari Ladan BSc, MSc, PhD, Zainab Mohammed BSc, MSc, PhD, Samson Wayah BSc, MSc, PhD, Ja'afar Mohammed BSc, MSc, PhD, Mohammed I Tahir BSc, MSc, PhD, Abdurrahman E Ahmad BSc, MSc, PhD, Yusuf Alhassan BSc, Daniel Tyoapine BSc, Abel S Agbaji BSc, MSc, PhD |
| المصدر: | Journal of Evidence-Based Integrative Medicine, Vol 29 (2024) |
| بيانات النشر: | SAGE Publishing, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Other systems of medicine LCC:Homeopathy |
| مصطلحات موضوعية: | Other systems of medicine, RZ201-999, Homeopathy, RX1-681 |
| الوصف: | Liver cancer is the most common cancer among males in Africa. The disease has a poor prognosis and its treatment is associated with toxicity and resistance. For this reason, numerous herbal combinations are being subjected to anticancer screening to circumvent the shortcomings of the conventional anticancer drugs. In the current study, the in vivo anti-cancer effects of the chloroform root extract of the herb, Clausena excavata Burm were investigated. Liver cancer was induced in mice by a single intraperitoneal injection of diethylnitrosamine (DEN) followed by oral administration of the promoter of carcinogenesis, 2-aminoacetyl fluorine that was mixed with the mice feed. The cytotoxicity of the root extract of C. excavata on liver cancer cells was investigated using liver enzyme, histology, DNA fragmentation and caspases assays. Real time qPCR was conducted to evaluate the effect of the extract on apoptotic genes. The findings revealed that the extract of C. excavata significantly decreased the progression of hepatocarcinogenesis and the toxicity-induced production of the liver enzymes, alanine and aspartate aminotransferases. The histological analyses of the liver tissues revealed evidence of apoptotic cell death. The extract also provoked significant ( p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2515-690X 2515690X |
| Relation: | https://doaj.org/toc/2515-690X |
| DOI: | 10.1177/2515690X241251558 |
| URL الوصول: | https://doaj.org/article/aee0384aba044616ad7f4fd1fd156780 |
| رقم الأكسشن: | edsdoj.0384aba044616ad7f4fd1fd156780 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2515690X |
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| DOI: | 10.1177/2515690X241251558 |