دورية أكاديمية
Reference ranges of T lymphocyte subsets by single-platform among healthy population in southwest China
| العنوان: | Reference ranges of T lymphocyte subsets by single-platform among healthy population in southwest China |
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| المؤلفون: | Bin Wei, Ying Guo, Liangjun Zhang, Huixiu Zhong, Qiang Miao, Lin Yan, Yangjuan Bai, Weihua Feng, Weiping Liu, Qian Niu, Yi Li |
| المصدر: | BMC Immunology, Vol 22, Iss 1, Pp 1-12 (2021) |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: | Reference ranges, T lymphocyte subsets, Single-platform, Southwest China, Indirect method, Immunologic diseases. Allergy, RC581-607 |
| الوصف: | Abstract Background Appropriate reference ranges of T lymphocyte subsets are essential for immune status evaluation of patients with immunological diseases. We aim to establish the age- and sex-related reference intervals of T lymphocyte subsets by single-platform for the southwest China population using the indirect method with the data resulting from 53,822 cases of periodic health examination individuals in the Laboratory Information System (LIS) of West China Hospital from 2018 to 2020. Methods We used the Box-Cox conversion combined with the Tukey method to normalize the data and eliminate the outliers, and the nonparametric method to estimate the 95% distribution reference intervals. Results We initially established the reference ranges of T lymphocyte subsets by single-platform among healthy population in southwest China by indirect method (See text for details). Using the standard normal deviate test (z-test) suggested by Harris and Boyd according to CLSI EP28-A3C, which is more scientific, we found the reference ranges of T lymphocyte subsets should be differentiated by ages and genders since the reference ranges of T lymphocyte subsets by single-platform in different ages and genders are significantly different. Conclusions We further demonstrated the absolute count of CD3 + T cell, CD3 + CD4 + T cell, CD3 + CD8 + T cell decreased with aging, which is more marked in men and CD3 + CD8 + T cell count, and the obtained reference intervals were superior to the reference intervals derived from the reagent specification currently in use. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1471-2172 73477648 |
| Relation: | https://doaj.org/toc/1471-2172 |
| DOI: | 10.1186/s12865-021-00474-0 |
| URL الوصول: | https://doaj.org/article/a0433a73477648e68d472acdc86ce567 |
| رقم الأكسشن: | edsdoj.0433a73477648e68d472acdc86ce567 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14712172 73477648 |
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| DOI: | 10.1186/s12865-021-00474-0 |