دورية أكاديمية
The Insulin-like Growth Factor-1 (G>A) and 5,10-methylenetetrahydrofolate Reductase (C677T) Gene Variants and the Serum Levels of Insulin-like Growth Factor-1, Insulin, and Homeostasis Model Assessment in Patients with Acne Vulgaris
| العنوان: | The Insulin-like Growth Factor-1 (G>A) and 5,10-methylenetetrahydrofolate Reductase (C677T) Gene Variants and the Serum Levels of Insulin-like Growth Factor-1, Insulin, and Homeostasis Model Assessment in Patients with Acne Vulgaris |
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| المؤلفون: | Sakineh Zinati-Saeed, Ebrahim Shakiba, Ziba Rahimi, Mona Akbari, Fariba Najafi, Fariborz Bahrehmand, Asad Vaisi-Raygani, Zohreh Rahimi, Ali Ebrahimi, Mehrali Rahimi |
| المصدر: | Iranian Journal of Pathology, Vol 15, Iss 1, Pp 23-29 (2020) |
| بيانات النشر: | Iranian Society of Pathology, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Pathology |
| مصطلحات موضوعية: | acne vulgaris, methylenetetrahydrofolate reductase, insulin-like growth factor-1, insulin, homeostasis model assessment, Pathology, RB1-214 |
| الوصف: | Background & Objective:To find an association between gene variants of insulin-like growth factor-1 (IGF-1) and 5,10-methylenetetrahydrofolate reductase (MTHFR) with the risk of acne vulgaris (AV).Methods:In a case-control study, we investigated 150 AV patients and 148 healthy individuals (aged 18-25 years) for the IGF-1 G>A and MTHFR C677T polymorphisms, as well as the serum levels of IGF-1, insulin, and the homeostasis model assessment of insulin resistance (HOMA-IR). The serum biochemical parameters and the genotypes of IGF-1 G>A and MTHFR C677T were detected by using appropriate kits and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods, respectively.Results:The frequencies of IGF-1 and the MTHFR polymorphisms were not significantly different comparing patients and controls. The serum level of IGF-1 was 179.8±72.8 µg/L in AV patients compared to 164.6±63.7 µg/L in controls (P=0.056). The serum level of insulin in female patients was significantly higher than controls. The HOMA was 3.54±5.6 in patients compared to 1.16±1.4 (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1735-5303 2345-3656 |
| Relation: | https://ijp.iranpath.org/article_37616_f4b6725a5f2ca9290f029e96b394f607.pdf; https://doaj.org/toc/1735-5303; https://doaj.org/toc/2345-3656 |
| DOI: | 10.30699/ijp.2019.105695.2098 |
| URL الوصول: | https://doaj.org/article/044d06e7123b44b2b599055ee46134e0 |
| رقم الأكسشن: | edsdoj.044d06e7123b44b2b599055ee46134e0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17355303 23453656 |
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| DOI: | 10.30699/ijp.2019.105695.2098 |