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Selective Anticancer Therapy Using Pro-Oxidant Drug-Loaded Chitosan–Fucoidan Nanoparticles

التفاصيل البيبلوغرافية
العنوان: Selective Anticancer Therapy Using Pro-Oxidant Drug-Loaded Chitosan–Fucoidan Nanoparticles
المؤلفون: Dae Gun Choi, Jayachandran Venkatesan, Min Suk Shim
المصدر: International Journal of Molecular Sciences, Vol 20, Iss 13, p 3220 (2019)
بيانات النشر: MDPI AG, 2019.
سنة النشر: 2019
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: chitosan, fucoidan, nanoparticles, piperlongumine, pro-oxidant cancer therapy, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Pro-oxidant therapy exploiting pro-oxidant drugs that can trigger cytotoxic oxidative stress in cancer cells has emerged as an innovative strategy for cancer-specific therapy. Piperlongumine (PL) has gained great interest as a novel pro-oxidant agent, because it has an ability to trigger cancer-specific apoptosis through the increase of oxidative stress in cancer cells. However, the use of PL is limited in the clinic because of its hydrophobic nature. In this study, chitosan- and fucoidan-based nanoparticles were prepared for the effective intracellular delivery of PL into cancer cells. Chitosan and fucoidan formed nanoparticles by ionic gelation. The chitosan- and fucoidan-based nanoparticles (CS−F NPs) effectively encapsulated PL, and increased its water solubility and bioavailability. CS−F NPs showed very low cytotoxicity in human prostate cancer cells, demonstrating its high potential for in vivo applications. The PL-loaded chitosan−fucoidan nanoparticles (PL-CS−F NPs) efficiently killed human prostate cancer cells via PL-induced intracellular reactive oxygen species (ROS) generation. This study demonstrates that CS−F NPs are promising natural polymer-based drug carriers for safe and effective PL delivery.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
Relation: https://www.mdpi.com/1422-0067/20/13/3220; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms20133220
URL الوصول: https://doaj.org/article/04669a59f984452587a6c215b25916ce
رقم الأكسشن: edsdoj.04669a59f984452587a6c215b25916ce
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
DOI:10.3390/ijms20133220