دورية أكاديمية
Selective Anticancer Therapy Using Pro-Oxidant Drug-Loaded Chitosan–Fucoidan Nanoparticles
العنوان: | Selective Anticancer Therapy Using Pro-Oxidant Drug-Loaded Chitosan–Fucoidan Nanoparticles |
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المؤلفون: | Dae Gun Choi, Jayachandran Venkatesan, Min Suk Shim |
المصدر: | International Journal of Molecular Sciences, Vol 20, Iss 13, p 3220 (2019) |
بيانات النشر: | MDPI AG, 2019. |
سنة النشر: | 2019 |
المجموعة: | LCC:Biology (General) LCC:Chemistry |
مصطلحات موضوعية: | chitosan, fucoidan, nanoparticles, piperlongumine, pro-oxidant cancer therapy, Biology (General), QH301-705.5, Chemistry, QD1-999 |
الوصف: | Pro-oxidant therapy exploiting pro-oxidant drugs that can trigger cytotoxic oxidative stress in cancer cells has emerged as an innovative strategy for cancer-specific therapy. Piperlongumine (PL) has gained great interest as a novel pro-oxidant agent, because it has an ability to trigger cancer-specific apoptosis through the increase of oxidative stress in cancer cells. However, the use of PL is limited in the clinic because of its hydrophobic nature. In this study, chitosan- and fucoidan-based nanoparticles were prepared for the effective intracellular delivery of PL into cancer cells. Chitosan and fucoidan formed nanoparticles by ionic gelation. The chitosan- and fucoidan-based nanoparticles (CS−F NPs) effectively encapsulated PL, and increased its water solubility and bioavailability. CS−F NPs showed very low cytotoxicity in human prostate cancer cells, demonstrating its high potential for in vivo applications. The PL-loaded chitosan−fucoidan nanoparticles (PL-CS−F NPs) efficiently killed human prostate cancer cells via PL-induced intracellular reactive oxygen species (ROS) generation. This study demonstrates that CS−F NPs are promising natural polymer-based drug carriers for safe and effective PL delivery. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1422-0067 |
Relation: | https://www.mdpi.com/1422-0067/20/13/3220; https://doaj.org/toc/1422-0067 |
DOI: | 10.3390/ijms20133220 |
URL الوصول: | https://doaj.org/article/04669a59f984452587a6c215b25916ce |
رقم الأكسشن: | edsdoj.04669a59f984452587a6c215b25916ce |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14220067 |
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DOI: | 10.3390/ijms20133220 |