دورية أكاديمية

Plerixafor-based mobilization and mononuclear cell counts in graft increased the risk of engraftment syndrome after autologous hematopoietic stem cell transplantation

التفاصيل البيبلوغرافية
العنوان: Plerixafor-based mobilization and mononuclear cell counts in graft increased the risk of engraftment syndrome after autologous hematopoietic stem cell transplantation
المؤلفون: Le-Qing Cao, Qi Wen, Bo-Ning Liu, Zhen-Yu Zhao, Xiao-Hui Zhang, Lan-Ping Xu, Huan Chen, Yu Wang, Lu Yu, Feng-Rong Wang, Xiao-Jun Huang, Xiao-Dong Mo
المصدر: Blood Science, Vol 6, Iss 3, p e00190 (2024)
بيانات النشر: Wolters Kluwer Health, 2024.
سنة النشر: 2024
المجموعة: LCC:Diseases of the blood and blood-forming organs
مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5
الوصف: Engraftment syndrome (ES) is one of the most common complications in the early phase after autologous hematopoietic stem cell transplantation (ASCT), and we aimed to evaluate the incidence and risk factors for ES patients receiving ASCT in the era of plerixafor-based mobilization. A total of 294 were enrolled, and 16.0% (n = 47) experienced ES after ASCT. The main clinical manifestations were fever (100%), diarrhea (78.7%), skin rash (23.4%), and hypoxemia/pulmonary edema (12.8%). Plerixafor-based mobilization was associated with higher counts of CD3+ cells, CD4+ cells, and CD8+ cells in grafts. In univariate analysis of the total cohort, age ≥60 years, receiving ASCT at complete remission (CR), higher number of mononuclear cell (MNC), CD3+ cell counts, CD4+ cells as well as CD8+ cells transfused and plerixafor-based mobilization were associated with ES after ASCT. Multivariate analysis showed that age ≥60 years (P = .0014), receiving ASCT at CR (P = .002), and higher number of MNC transfused (P = .026) were associated with ES in total cohort. In plasma cell disease subgroup, age ≥60 years (P = .013), plerixafor-based mobilization (P = .036), and receiving ASCT at CR (P = .002) were associated with ES. Patients with more risk factors had a higher risk of ES. The 1-year probabilities of relapse, non-relapse mortality, and survival were comparable between patients with and without ES. Thus, plerixafor-based mobilization may influence the composition of T lymphocytes in grafts and increase the risk of ES, particularly in patients with plasma cell disease.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2543-6368
00000000
Relation: http://journals.lww.com/10.1097/BS9.0000000000000190; https://doaj.org/toc/2543-6368
DOI: 10.1097/BS9.0000000000000190
URL الوصول: https://doaj.org/article/04d52360bcec4f709b64f0eb53dc1a1f
رقم الأكسشن: edsdoj.04d52360bcec4f709b64f0eb53dc1a1f
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:25436368
00000000
DOI:10.1097/BS9.0000000000000190