دورية أكاديمية
Simple Does Not Mean Trivial: Behavior of Phosphatidic Acid in Lipid Mono- and Bilayers
| العنوان: | Simple Does Not Mean Trivial: Behavior of Phosphatidic Acid in Lipid Mono- and Bilayers |
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| المؤلفون: | Dominik Drabik, Aleksander Czogalla |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 21, p 11523 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | phosphatidic acid, molecular dynamics, flicker noise spectroscopy, Langmuir monolayers, bending rigidity, area compressibility, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Phosphatidic acid (PA) is one of the simplest membrane phospholipids, yet it plays a crucial role in various biologically relevant processes that take place in cells. Since PA generation may be triggered by a variety of factors, very often of antagonistic character, the specific nature of physiological responses driven by PA is not clear. In order to shed more light on these issues, we carried out a systematic characterization of membranes containing one of the three biologically significant PA molecular species. The effect of these molecules on the properties of membranes composed of phosphatidylcholine and/or cholesterol was assessed in a multidisciplinary approach, including molecular dynamic simulations, flicker noise spectroscopy, and Langmuir monolayer isotherms. The first enables the determination of various macroscopic and microscopic parameters such as lateral diffusion, membrane thickness, and defect analysis. The obtained data revealed a strong interaction between unsaturated PA species and phosphatidylcholine. On the other hand, the behavior of saturated PA was greatly influenced by cholesterol. Additionally, a strong effect on mechanical properties was observed in the case of three-component systems, which could not be explained by the simple extrapolation of parameters of the corresponding two-component systems. Our data show that various PA species are not equivalent in terms of their influence on lipid mono- and bilayers and that membrane composition/properties, particularly those related to the presence of cholesterol, may strongly modulate PA behavior. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 22211152 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/22/21/11523; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms222111523 |
| URL الوصول: | https://doaj.org/article/e051211aa1db4632ac6ede3add923650 |
| رقم الأكسشن: | edsdoj.051211aa1db4632ac6ede3add923650 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22211152 14220067 16616596 |
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| DOI: | 10.3390/ijms222111523 |