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Tetramethylammonium Fluoride: Fundamental Properties and Applications in C-F Bond-Forming Reactions and as a Base

التفاصيل البيبلوغرافية
العنوان: Tetramethylammonium Fluoride: Fundamental Properties and Applications in C-F Bond-Forming Reactions and as a Base
المؤلفون: Vladimir Iashin, Tom Wirtanen, Jesus E. Perea-Buceta
المصدر: Catalysts, Vol 12, Iss 2, p 233 (2022)
بيانات النشر: MDPI AG, 2022.
سنة النشر: 2022
المجموعة: LCC:Chemical technology
LCC:Chemistry
مصطلحات موضوعية: tetramethylammonium fluoride, TMAF, solvation effects, nucleophilic fluorination, sustainable industrial fluorination, SNAr, Chemical technology, TP1-1185, Chemistry, QD1-999
الوصف: Nucleophilic ionic sources of fluoride are essential reagents in the synthetic toolbox to access high added-value fluorinated building blocks unattainable by other means. In this review, we provide a concise description and rationale of the outstanding features of one of these reagents, tetramethylammonium fluoride (TMAF), as well as disclosing the different methods for its preparation, and how its physicochemical properties and solvation effects in different solvents are intimately associated with its reactivity. Furthermore, herein we also comprehensively describe its historic and recent utilization, up to December 2021, in C-F bond-forming reactions with special emphasis on nucleophilic aromatic substitution fluorinations with a potential sustainable application in industrial settings, as well as its use as a base capable of rendering unprecedented transformations.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2073-4344
Relation: https://www.mdpi.com/2073-4344/12/2/233; https://doaj.org/toc/2073-4344
DOI: 10.3390/catal12020233
URL الوصول: https://doaj.org/article/05550cca2a9940a49156e677a808c747
رقم الأكسشن: edsdoj.05550cca2a9940a49156e677a808c747
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20734344
DOI:10.3390/catal12020233