دورية أكاديمية
Low-dose ionizing radiation generates a hormetic response to modify lipid metabolism in Chlorella sorokiniana
| العنوان: | Low-dose ionizing radiation generates a hormetic response to modify lipid metabolism in Chlorella sorokiniana |
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| المؤلفون: | Marina Stanić, Mima Jevtović, Snežana Kovačević, Milena Dimitrijević, Jelena Danilović Luković, Owen A. McIntosh, Bernd Zechmann, Alessandro Marco Lizzul, Ivan Spasojević, Jon K. Pittman |
| المصدر: | Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | Biology (General), QH301-705.5 |
| الوصف: | Abstract Algal biomass is a viable source of chemicals and metabolites for various energy, nutritional, medicinal and agricultural uses. While stresses have commonly been used to induce metabolite accumulation in microalgae in attempts to enhance high-value product yields, this is often very detrimental to growth. Therefore, understanding how to modify metabolism without deleterious consequences is highly beneficial. We demonstrate that low-doses (1–5 Gy) of ionizing radiation in the X-ray range induces a non-toxic, hormetic response in microalgae to promote metabolic activation. We identify specific radiation exposure parameters that give reproducible metabolic responses in Chlorella sorokiniana caused by transcriptional changes. This includes up-regulation of >30 lipid metabolism genes, such as genes encoding an acetyl-CoA carboxylase subunit, phosphatidic acid phosphatase, lysophosphatidic acid acyltransferase, and diacylglycerol acyltransferase. The outcome is an increased lipid yield in stationary phase cultures by 25% in just 24 hours, without any negative effects on cell viability or biomass. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2399-3642 19210329 |
| Relation: | https://doaj.org/toc/2399-3642 |
| DOI: | 10.1038/s42003-024-06526-6 |
| URL الوصول: | https://doaj.org/article/0557f754a84f43ebaf774b19210329ba |
| رقم الأكسشن: | edsdoj.0557f754a84f43ebaf774b19210329ba |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 23993642 19210329 |
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| DOI: | 10.1038/s42003-024-06526-6 |