دورية أكاديمية
Red blood cell-derived materials for cancer therapy: Construction, distribution, and applications
| العنوان: | Red blood cell-derived materials for cancer therapy: Construction, distribution, and applications |
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| المؤلفون: | Jianghua Ding, Xinjing Ding, Weifang Liao, Zhihui Lu |
| المصدر: | Materials Today Bio, Vol 24, Iss , Pp 100913- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Red blood cell (RBC), RBC hitchhiking, Extracellular vesicles, Nanometer materials, Cancer, Drug delivery system (DDS), Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Cancer has become an increasingly important public health issue owing to its high morbidity and mortality rates. Although traditional treatment methods are relatively effective, they have limitations such as highly toxic side effects, easy drug resistance, and high individual variability. Meanwhile, emerging therapies remain limited, and their actual anti-tumor effects need to be improved. Nanotechnology has received considerable attention for its development and application. In particular, artificial nanocarriers have emerged as a crucial approach for tumor therapy. However, certain deficiencies persist, including immunogenicity, permeability, targeting, and biocompatibility. The application of erythrocyte-derived materials will help overcome the above problems and enhance therapeutic effects. Erythrocyte-derived materials can be acquired via the application of physical and chemical techniques from natural erythrocyte membranes, or through the integration of these membranes with synthetic inner core materials using cell membrane biomimetic technology. Their natural properties such as biocompatibility and long circulation time make them an ideal choice for drug delivery or nanoparticle biocoating. Thus, red blood cell-derived materials are widely used in the field of biomedicine. However, further studies are required to evaluate their efficacy, in vivo metabolism, preparation, design, and clinical translation. Based on the latest research reports, this review summarizes the biology, synthesis, characteristics, and distribution of red blood cell-derived materials. Furthermore, we provide a reference for further research and clinical transformation by comprehensively discussing the applications and technical challenges faced by red blood cell-derived materials in the treatment of malignant tumors. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2590-0064 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2590006423003733; https://doaj.org/toc/2590-0064 |
| DOI: | 10.1016/j.mtbio.2023.100913 |
| URL الوصول: | https://doaj.org/article/05661e16c0504cbfa85e2519231d8a59 |
| رقم الأكسشن: | edsdoj.05661e16c0504cbfa85e2519231d8a59 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 25900064 |
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| DOI: | 10.1016/j.mtbio.2023.100913 |