دورية أكاديمية
Comparison of the antiemetic effect of ramosetron with ondansetron in patients undergoing microvascular decompression with retromastoid craniotomy: a preliminary report
العنوان: | Comparison of the antiemetic effect of ramosetron with ondansetron in patients undergoing microvascular decompression with retromastoid craniotomy: a preliminary report |
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المؤلفون: | Sang Hee Ha, Hyunzu Kim, Hyang Mi Ju, Da Jung Nam, Kyeong Tae Min |
المصدر: | Korean Journal of Anesthesiology, Vol 68, Iss 4, Pp 386-391 (2015) |
بيانات النشر: | Korean Society of Anesthesiologists, 2015. |
سنة النشر: | 2015 |
المجموعة: | LCC:Anesthesiology |
مصطلحات موضوعية: | microvascular decompression, postoperative nausea and vomiting, ramosetron, Anesthesiology, RD78.3-87.3 |
الوصف: | BackgroundMicrovascular decompression with retromastoid craniotomy carries an especially high risk of postoperative nausea and vomiting. In this study, we compare the antiemetic efficacy of ramosetron and ondansetron in patients undergoing microvascular decompression with retromastoid craniotomy.MethodsUsing balanced anesthesia with sevoflurane and remifentanil infusion, ondansetron 8 mg (group O, n = 31) or ramosetron 0.3 mg (group R, n = 31) was administered at the dural closure. The incidence and severity of postoperative nausea and vomiting, required rescue medications and the incidence of side effects were measured at post-anesthetic care unit, 6, 24 and 48 hours postoperatively. Independent t-tests and the chi-square test or Fisher's exact test were used for statistical analyses.ResultsThere were no differences in the demographic data between groups, except for a slightly longer anesthetic duration of group R (P = 0.01). The overall postoperative 48 hour incidences of nausea and vomiting were 93.6 and 61.3% (group O), and 87.1 and 51.6% (group R), respectively. Patients in group R showed a less severe degree of nausea (P = 0.02) and a lower incidence of dizziness (P = 0.04) between 6 and 24 hours.ConclusionsThe preventive efficacy of ramosetron when used for postoperative nausea and vomiting was similar to that of ondansetron up to 48 hours after surgery in patients undergoing microvascular decompression with retromastoid craniotomy. A larger randomized controlled trial is needed to confirm our findings. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2005-6419 2005-7563 |
Relation: | http://ekja.org/upload/pdf/kjae-68-386.pdf; https://doaj.org/toc/2005-6419; https://doaj.org/toc/2005-7563 |
DOI: | 10.4097/kjae.2015.68.4.386 |
URL الوصول: | https://doaj.org/article/0587edd8b2674822b84da0de27743dfc |
رقم الأكسشن: | edsdoj.0587edd8b2674822b84da0de27743dfc |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 20056419 20057563 |
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DOI: | 10.4097/kjae.2015.68.4.386 |