دورية أكاديمية
Maternal exposure to di-(2-ethylhexyl) phthalate impaired the social interaction via activating microglia in male pups
| العنوان: | Maternal exposure to di-(2-ethylhexyl) phthalate impaired the social interaction via activating microglia in male pups |
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| المؤلفون: | Zhixia Wei, Rui Fang, Ying Wang, Jing Dong |
| المصدر: | Ecotoxicology and Environmental Safety, Vol 272, Iss , Pp 116069- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Environmental pollution LCC:Environmental sciences |
| مصطلحات موضوعية: | Di-(2-ethylhexyl) phthalate, JAK2/STAT3 signaling pathway, Microglia, Pro-inflammatory factors, Social interaction, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350 |
| الوصف: | Di-(2-ethylhexyl) phthalate (DEHP), a common endocrine-disrupting chemical (EDC), is widely used in daily articles, early exposure to DEHP is associated with many behavioral changes in pups. This study aimed to investigate the effects and underlying mechanisms of maternal exposure to DEHP on the impaired social interaction in pups. Pregnant rats were administered 0, 30, 300, or 750 mg/kg/d DEHP daily by oral gavage. Highly aggressive proliferating immortalized (HAPI) cells were treated with mono-(2-ethylhexyl) phthalate (MEHP) and tyrosine phosphorylation inhibitor (AG490). Our results showed that DEHP exposure induced the activation of microglias (MGs) via activating the janus kinase 2 / signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway, and increased the level of pro-inflammatory factors, then impaired the social behavior in male pups, but not female pups. Moreover, MEHP exposure could also activate HAPI via activating this signaling pathway, and AG490 could inhibit the activation of this signaling pathway caused by MEHP. Therefore, we indicated that maternal exposure to DEHP could cause the gender-specific impaired social interaction in pups that might be related to the activation of MGs. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0147-6513 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S0147651324001441; https://doaj.org/toc/0147-6513 |
| DOI: | 10.1016/j.ecoenv.2024.116069 |
| URL الوصول: | https://doaj.org/article/058852daa93b4745bd8d93bfc7a77645 |
| رقم الأكسشن: | edsdoj.058852daa93b4745bd8d93bfc7a77645 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 01476513 |
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| DOI: | 10.1016/j.ecoenv.2024.116069 |