دورية أكاديمية
Acidosis and acute kidney injury in severe malaria
| العنوان: | Acidosis and acute kidney injury in severe malaria |
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| المؤلفون: | Natthida Sriboonvorakul, Aniruddha Ghose, M. Mahtab Uddin Hassan, Md. Amir Hossain, M. Abul Faiz, Sasithon Pukrittayakamee, Kesinee Chotivanich, Yaowalark Sukthana, Stije J. Leopold, Katherine Plewes, Nicholas P. J. Day, Nicholas J. White, Joel Tarning, Arjen M. Dondorp |
| المصدر: | Malaria Journal, Vol 17, Iss 1, Pp 1-8 (2018) |
| بيانات النشر: | BMC, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Arctic medicine. Tropical medicine LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | Severe malaria, Acidosis, Acute kidney injury, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Abstract Background In severe falciparum malaria metabolic acidosis and acute kidney injury (AKI) are independent predictors of a fatal outcome in all age groups. The relationship between plasma acids, urine acids and renal function was investigated in adult patients with acute falciparum malaria. Methods Plasma and urinary acids which previously showed increased concentrations in proportion to disease severity in patients with severe falciparum malaria were quantified. Patients with uncomplicated malaria, sepsis and healthy volunteers served as comparator groups. Multiple regression and multivariate analysis were used to assess the relationship between organic acid concentrations and clinical syndromes, in particular AKI. Results Patients with severe malaria (n = 90), uncomplicated malaria (n = 94), non-malaria sepsis (n = 19), and healthy volunteers (n = 61) were included. Univariate analysis showed that both plasma and creatinine-adjusted urine concentrations of p-hydroxyphenyllactic acid (pHPLA) were higher in severe malaria patients with AKI (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1475-2875 |
| Relation: | http://link.springer.com/article/10.1186/s12936-018-2274-9; https://doaj.org/toc/1475-2875 |
| DOI: | 10.1186/s12936-018-2274-9 |
| URL الوصول: | https://doaj.org/article/059e025d76924aaca904668df48f344f |
| رقم الأكسشن: | edsdoj.059e025d76924aaca904668df48f344f |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14752875 |
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| DOI: | 10.1186/s12936-018-2274-9 |