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The association of systemic microvascular changes with lung function and lung density: a cross-sectional study.

التفاصيل البيبلوغرافية
العنوان: The association of systemic microvascular changes with lung function and lung density: a cross-sectional study.
المؤلفون: Bianca Harris, Ronald Klein, Michael Jerosch-Herold, Eric A Hoffman, Firas S Ahmed, David R Jacobs, Barbara E K Klein, Tien Y Wong, Joao A C Lima, Mary Frances Cotch, R Graham Barr
المصدر: PLoS ONE, Vol 7, Iss 12, p e50224 (2012)
بيانات النشر: Public Library of Science (PLoS), 2012.
سنة النشر: 2012
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Smoking causes endothelial dysfunction and systemic microvascular disease with resultant end-organ damage in the kidneys, eyes and heart. Little is known about microvascular changes in smoking-related lung disease. We tested if microvascular changes in the retina, kidneys and heart were associated with obstructive spirometry and low lung density on computed tomography. The Multi-Ethnic Study of Atherosclerosis recruited participants age 45-84 years without clinical cardiovascular disease. Measures of microvascular function included retinal arteriolar and venular caliber, urine albumin-to-creatinine ratio and, in a subset, myocardial blood flow on magnetic resonance imaging. Spirometry was measured following ATS/ERS guidelines. Low attenuation areas (LAA) were measured on lung fields of cardiac computed tomograms. Regression models adjusted for pulmonary and cardiac risk factors, medications and body size. Among 3,397 participants, retinal venular caliber was inversely associated with forced expiratory volume in one second (FEV(1)) (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23284634/pdf/?tool=EBI; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0050224
URL الوصول: https://doaj.org/article/05a047ef14624fefb01f987aa056c52a
رقم الأكسشن: edsdoj.05a047ef14624fefb01f987aa056c52a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0050224