دورية أكاديمية
Dementia with Lewy bodies: an update and outlook
| العنوان: | Dementia with Lewy bodies: an update and outlook |
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| المؤلفون: | Tiago Fleming Outeiro, David J. Koss, Daniel Erskine, Lauren Walker, Marzena Kurzawa-Akanbi, David Burn, Paul Donaghy, Christopher Morris, John-Paul Taylor, Alan Thomas, Johannes Attems, Ian McKeith |
| المصدر: | Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-18 (2019) |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Neurology. Diseases of the nervous system LCC:Geriatrics |
| مصطلحات موضوعية: | Dementia with Lewy bodies, Alpha-synuclein, Dementia, Alzheimer’s disease, Biomarkers, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6 |
| الوصف: | Abstract Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder producing progressive cognitive decline that interferes with normal life and daily activities. Neuropathologically, DLB is characterised by the accumulation of aggregated α-synuclein protein in Lewy bodies and Lewy neurites, similar to Parkinson’s disease (PD). Extrapyramidal motor features characteristic of PD, are common in DLB patients, but are not essential for the clinical diagnosis of DLB. Since many PD patients develop dementia as disease progresses, there has been controversy about the separation of DLB from PD dementia (PDD) and consensus reports have put forward guidelines to assist clinicians in the identification and management of both syndromes. Here, we present basic concepts and definitions, based on our current understanding, that should guide the community to address open questions that will, hopefully, lead us towards improved diagnosis and novel therapeutic strategies for DLB and other synucleinopathies. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1750-1326 |
| Relation: | http://link.springer.com/article/10.1186/s13024-019-0306-8; https://doaj.org/toc/1750-1326 |
| DOI: | 10.1186/s13024-019-0306-8 |
| URL الوصول: | https://doaj.org/article/ee05c131d9894b98a2318875d6b68045 |
| رقم الأكسشن: | edsdoj.05c131d9894b98a2318875d6b68045 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 17501326 |
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| DOI: | 10.1186/s13024-019-0306-8 |