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Preparation and Properties of Double-Crosslinked Hydroxyapatite Composite Hydrogels

التفاصيل البيبلوغرافية
العنوان: Preparation and Properties of Double-Crosslinked Hydroxyapatite Composite Hydrogels
المؤلفون: Benbo Zhao, Mingda Zhao, Liming Li, Shixiong Sun, Heping Yu, Yuan Cheng, Yuedi Yang, Yujiang Fan, Yong Sun
المصدر: International Journal of Molecular Sciences, Vol 23, Iss 17, p 9962 (2022)
بيانات النشر: MDPI AG, 2022.
سنة النشر: 2022
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: hyaluronic acid, gelatin, dopamine, double crosslinked, hydroxyapatite-enhanced hydrogel, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Natural polymer hydrogels have good mechanical properties and biocompatibility. This study designed hydroxyapatite-enhanced photo-oxidized double-crosslinked hydrogels. Hyaluronic acid (HA) and gelatin (Gel) were modified with methacrylate anhydride. The catechin group was further introduced into the HA chain inspired by the adhesion chemistry of marine mussels. Hence, the double-crosslinked hydrogel (HG) was formed by the photo-crosslinking of double bonds and the oxidative-crosslinking of catechins. Moreover, hydroxyapatite was introduced into HG to form hydroxyapatite-enhanced hydrogels (HGH). The results indicate that, with an increase in crosslinking network density, the stiffness of hydrogels became higher; these hydrogels have more of a compact pore structure, their anti-degradation property is improved, and swelling property is reduced. The introduction of hydroxyapatite greatly improved the mechanical properties of hydrogels, but there is no change in the stability and crosslinking network structure of hydrogels. These inorganic phase-enhanced hydrogels were expected to be applied to tissue engineering scaffolds.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
1661-6596
Relation: https://www.mdpi.com/1422-0067/23/17/9962; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms23179962
URL الوصول: https://doaj.org/article/d05ce9f04f74406190a50e6bbff626e5
رقم الأكسشن: edsdoj.05ce9f04f74406190a50e6bbff626e5
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
16616596
DOI:10.3390/ijms23179962