دورية أكاديمية
Recurrent Cerebral Venous Sinus Thrombosis Occurred in an Acute Lymphoblastic Leukemia Child with Mutated Lipoprotein Lipase Gene during Asparaginase Therapy
| العنوان: | Recurrent Cerebral Venous Sinus Thrombosis Occurred in an Acute Lymphoblastic Leukemia Child with Mutated Lipoprotein Lipase Gene during Asparaginase Therapy |
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| المؤلفون: | Shiyuan Wang, Jun Li, Ying Li, Xiaoming Liu, Lixian Chang, Beibei Zhao, Li Zhang, Yao Zou, Min Ruan, Xiaofan Zhu |
| المصدر: | Global Medical Genetics, Vol 11, Iss 03, Pp 214-219 (2024) |
| بيانات النشر: | Georg Thieme Verlag KG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Genetics LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | acute lymphoblastic leukemia, gene mutation, L-Asparaginase, cerebral venous sinus thrombosis, Genetics, QH426-470, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Cerebral venous sinus thrombosis (CVST) and hyperlipidemia are severe complications of L-Asparaginase (L-Asp) during the treatment of B-cell acute lymphoblastic leukemia (B-ALL). Herein, we reported a 9-year-old B-ALL boy who underwent abnormal hypertriglyceridemia and CVST presenting as seizures and disturbance of consciousness twice during the induction therapy. Fortunately, he survived treatment with anticoagulant and lipid-lowering therapy. No thrombophilia-related gene mutation was detected, but a heterozygous mutation in lipoprotein lipase (LPL) gene was identified. His neurological symptoms were managed with short-term anticoagulant therapy and long-term lipid-lowering therapy. This case illustrated the manifestation and potential pathogenesis of CVST and highlighted the essentiality of screening baseline lipid profile and dyslipidemia- and thrombophilia-related gene mutation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2699-9404 |
| Relation: | https://doaj.org/toc/2699-9404 |
| DOI: | 10.1055/s-0044-1788043 |
| URL الوصول: | https://doaj.org/article/06015c21da73438fb6f8b624df18fedd |
| رقم الأكسشن: | edsdoj.06015c21da73438fb6f8b624df18fedd |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 26999404 |
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| DOI: | 10.1055/s-0044-1788043 |