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Quantification of volumetric morphometry and optical property in the cortex of human cerebellum at micrometer resolution

التفاصيل البيبلوغرافية
العنوان: Quantification of volumetric morphometry and optical property in the cortex of human cerebellum at micrometer resolution
المؤلفون: Chao J. Liu, William Ammon, Viviana Siless, Morgan Fogarty, Ruopeng Wang, Alessia Atzeni, Iman Aganj, Juan Eugenio Iglesias, Lilla Zöllei, Bruce Fischl, Jeremy D. Schmahmann, Hui Wang
المصدر: NeuroImage, Vol 244, Iss , Pp 118627- (2021)
بيانات النشر: Elsevier, 2021.
سنة النشر: 2021
المجموعة: LCC:Neurosciences. Biological psychiatry. Neuropsychiatry
مصطلحات موضوعية: Cerebellum, Polarization-sensitive optical coherence tomography, Layer thickness, Cell density, Myelin, Cross-subject variability, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
الوصف: The surface of the human cerebellar cortex is much more tightly folded than the cerebral cortex. Volumetric analysis of cerebellar morphometry in magnetic resonance imaging studies suffers from insufficient resolution, and therefore has had limited impact on disease assessment. Automatic serial polarization-sensitive optical coherence tomography (as-PSOCT) is an emerging technique that offers the advantages of microscopic resolution and volumetric reconstruction of large-scale samples. In this study, we reconstructed multiple cubic centimeters of ex vivo human cerebellum tissue using as-PSOCT. The morphometric and optical properties of the cerebellar cortex across five subjects were quantified. While the molecular and granular layers exhibited similar mean thickness in the five subjects, the thickness varied greatly in the granular layer within subjects. Layer-specific optical property remained homogenous within individual subjects but showed higher cross-subject variability than layer thickness. High-resolution volumetric morphometry and optical property maps of human cerebellar cortex revealed by as-PSOCT have great potential to advance our understanding of cerebellar function and diseases.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1095-9572
69497583
Relation: http://www.sciencedirect.com/science/article/pii/S1053811921009009; https://doaj.org/toc/1095-9572
DOI: 10.1016/j.neuroimage.2021.118627
URL الوصول: https://doaj.org/article/a066509f7d69497583ddfaa33f5b288a
رقم الأكسشن: edsdoj.066509f7d69497583ddfaa33f5b288a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:10959572
69497583
DOI:10.1016/j.neuroimage.2021.118627