دورية أكاديمية
Cannabinoid exposure and altered DNA methylation in rat and human sperm
| العنوان: | Cannabinoid exposure and altered DNA methylation in rat and human sperm |
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| المؤلفون: | Susan K. Murphy, Nilda Itchon-Ramos, Zachary Visco, Zhiqing Huang, Carole Grenier, Rose Schrott, Kelly Acharya, Marie-Helene Boudreau, Thomas M. Price, Douglas J. Raburn, David L. Corcoran, Joseph E. Lucas, John T. Mitchell, F. Joseph McClernon, Marty Cauley, Brandon J. Hall, Edward D. Levin, Scott H. Kollins |
| المصدر: | Epigenetics, Vol 13, Iss 12, Pp 1208-1221 (2018) |
| بيانات النشر: | Taylor & Francis Group, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Genetics |
| مصطلحات موضوعية: | cannabis, tetrahydrocannabinol, sperm, dna methylation, epigenetic reprogramming, rat, human, Genetics, QH426-470 |
| الوصف: | Little is known about the reproductive effects of paternal cannabis exposure. We evaluated associations between cannabis or tetrahydrocannabinol (THC) exposure and altered DNA methylation in sperm from humans and rats, respectively. DNA methylation, measured by reduced representation bisulfite sequencing, differed in the sperm of human users from non-users by at least 10% at 3,979 CpG sites. Pathway analyses indicated Hippo Signaling and Pathways in Cancer as enriched with altered genes (Bonferroni p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1559-2294 1559-2308 15592294 |
| Relation: | https://doaj.org/toc/1559-2294; https://doaj.org/toc/1559-2308 |
| DOI: | 10.1080/15592294.2018.1554521 |
| URL الوصول: | https://doaj.org/article/e06953ad05d74a9fa4881a6ad9924262 |
| رقم الأكسشن: | edsdoj.06953ad05d74a9fa4881a6ad9924262 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 15592294 15592308 |
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| DOI: | 10.1080/15592294.2018.1554521 |