دورية أكاديمية
In Situ Absorption in Rat Intestinal Tract of Solid Dispersion of Annonaceous Acetogenins
| العنوان: | In Situ Absorption in Rat Intestinal Tract of Solid Dispersion of Annonaceous Acetogenins |
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| المؤلفون: | Yun-Jie Dang, Han-Zhou Feng, Limei Zhang, Chun-Hui Hu, Chun-Yan Zhu |
| المصدر: | Gastroenterology Research and Practice, Vol 2012 (2012) |
| بيانات النشر: | Wiley, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Isolated from Annona squamosa L, Annonaceous acetogenins (ACGs) exhibit a broad range of biological properties yet absorbed badly due to the low solubility. Solid dispersion in polyethylene glycol 4000 (PEG 4000) has been developed to increase the solubility and oral absorption of ACGs. The formulation of ACGS-solid dispersion was optimized by a simplex lattice experiment design and carried out by a solvent-fusion method. We studied the absorption property of ACGs in rat’s intestine, which showed there was a good absorption and uptake percentages with solid dispersion. The study on uptake percentage in different regions of rat’s intestine attested that the duodenum had the best permeability, followed by jejunum, ileum, and colon in order with no significant differences. So the paper drew the conclusion that solid dispersion could improve the solubility and oral absorption of annonaceous acetogenins. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1687-6121 1687-630X 98160443 |
| Relation: | https://doaj.org/toc/1687-6121; https://doaj.org/toc/1687-630X |
| DOI: | 10.1155/2012/879676 |
| URL الوصول: | https://doaj.org/article/d06d4ecb43474edd98160443c656d186 |
| رقم الأكسشن: | edsdoj.06d4ecb43474edd98160443c656d186 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16876121 1687630X 98160443 |
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| DOI: | 10.1155/2012/879676 |