دورية أكاديمية
Biophysical studies of cancer cells’ traverse-vessel behaviors under different pressures revealed cells’ motion state transition
| العنوان: | Biophysical studies of cancer cells’ traverse-vessel behaviors under different pressures revealed cells’ motion state transition |
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| المؤلفون: | Xiao Li, Jialin Shi, Ziqing Gao, Jian Xu, Shujing Wang, Xin Li, Qi Ouyang, Chunxiong Luo |
| المصدر: | Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022) |
| بيانات النشر: | Nature Portfolio, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract Circulating tumor cells (CTCs) survive in the bloodstream and then seed and invade to foster tumor metastasis. The arrest of cancer cells is favored by permissive flow forces and geometrical constraints. Through the use of high-throughput microfluidic devices designed to mimic capillary-sized vessels, we applied pressure differences to cancer cells (MCF-7 cell line) and recorded the cell traverse-vessel behaviors. Our results showed that cancer cells transform from a Newtonian droplet state to an adhesion/migration state when cancer cells traverse artificial vessels. To explain these phenomena, a modified Newtonian droplet model was also proposed. These phenomena and the modified model may reveal how CTCs in the blood seed and invade vessels under suitable conditions. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-022-11047-5 |
| URL الوصول: | https://doaj.org/article/d06e63ddd8ed43d9902e7a10bea80031 |
| رقم الأكسشن: | edsdoj.06e63ddd8ed43d9902e7a10bea80031 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-022-11047-5 |