دورية أكاديمية
Extracellular Vesicles: Interplay with the Extracellular Matrix and Modulated Cell Responses
| العنوان: | Extracellular Vesicles: Interplay with the Extracellular Matrix and Modulated Cell Responses |
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| المؤلفون: | Aleen Al Halawani, Suzanne M. Mithieux, Giselle C. Yeo, Elham Hosseini-Beheshti, Anthony S. Weiss |
| المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 6, p 3389 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | extracellular vesicles, exosomes, microvesicles, extracellular matrix, mesenchymal stem cells, wound healing, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The discovery that cells secrete extracellular vesicles (EVs), which carry a variety of regulatory proteins, nucleic acids, and lipids, has shed light on the sophisticated manner by which cells can communicate and accordingly function. The bioactivity of EVs is not only defined by their internal content, but also through their surface associated molecules, and the linked downstream signaling effects they elicit in target cells. The extracellular matrix (ECM) contains signaling and structural molecules that are central to tissue maintenance and repair. Recently, a subset of EVs residing within the extracellular matrix has been identified. Although some roles have been proposed for matrix-bound vesicles, their role as signaling molecules within the ECM is yet to be explored. Given the close association of EVs and the ECM, it is not surprising that EVs partly mediate repair and regeneration by modulating matrix deposition and degradation through their cellular targets. This review addresses unique EV features that allow them to interact with and navigate through the ECM, describes how their release and content is influenced by the ECM, and emphasizes the emerging role of stem-cell derived EVs in tissue repair and regeneration through their matrix-modulating properties. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/23/6/3389; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms23063389 |
| URL الوصول: | https://doaj.org/article/d07314beb2db40589b49474d5af34809 |
| رقم الأكسشن: | edsdoj.07314beb2db40589b49474d5af34809 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms23063389 |