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Ketosis Onset Type 2 Diabetes Had Better Islet β-Cell Function and More Serious Insulin Resistance

التفاصيل البيبلوغرافية
العنوان: Ketosis Onset Type 2 Diabetes Had Better Islet β-Cell Function and More Serious Insulin Resistance
المؤلفون: Hongyun Lu, Fang Hu, Yingjuan Zeng, Lingling Zou, Shunkui Luo, Ying Sun, Hong Liu, Liao Sun
المصدر: Journal of Diabetes Research, Vol 2014 (2014)
بيانات النشر: Wiley, 2014.
سنة النشر: 2014
المجموعة: LCC:Diseases of the endocrine glands. Clinical endocrinology
مصطلحات موضوعية: Diseases of the endocrine glands. Clinical endocrinology, RC648-665
الوصف: Diabetic ketosis had been identified as a characteristic of type 1 diabetes mellitus (T1DM), but now emerging evidence has identified that they were diagnosed as T2DM after long time follow up. This case control study was aimed at comparing the clinical characteristic, β-cell function, and insulin resistance of ketosis and nonketotic onset T2DM and providing evidence for treatment selection. 140 cases of newly diagnosed T2DM patients were divided into ketosis (62 cases) and nonketotic onset group (78 cases). After correction of hyperglycemia and ketosis with insulin therapy, plasma C-peptide concentrations were measured at 0, 0.5, 1, 2, and 3 hours after 75 g glucose oral administration. Area under the curve (AUC) of C-peptide was calculated. Homoeostasis model assessment was used to estimate basal β-cell function (HOMA-β) and insulin resistance (HOMA-IR). Our results showed that ketosis onset group had higher prevalence of nonalcoholic fatty liver disease (NAFLD) than nonketotic group (P=0.04). Ketosis onset group had increased plasma C-peptide levels at 0 h, 0.5 h, and 3 h and higher AUC0–0.5, AUC0–1, AUC0–3 (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2314-6745
2314-6753
Relation: https://doaj.org/toc/2314-6745; https://doaj.org/toc/2314-6753
DOI: 10.1155/2014/510643
URL الوصول: https://doaj.org/article/0752367ec26b4bec9ebd8575849718ed
رقم الأكسشن: edsdoj.0752367ec26b4bec9ebd8575849718ed
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23146745
23146753
DOI:10.1155/2014/510643