دورية أكاديمية
An exploratory study of adolescent response to fluoxetine using psychological and biological predictors
| العنوان: | An exploratory study of adolescent response to fluoxetine using psychological and biological predictors |
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| المؤلفون: | Ada H. Zohar, Tamar Eilat, Maya Amitai, Michal Taler, Romi Bari, Alon Chen, Alan Apter, Avraham Weizman, Silvana Fennig |
| المصدر: | PeerJ, Vol 6, p e4240 (2018) |
| بيانات النشر: | PeerJ Inc., 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medicine LCC:Biology (General) |
| مصطلحات موضوعية: | Fluoxetine, Adolescent, Treatment response, Ex post-facto study, Type D personality, Personality, Medicine, Biology (General), QH301-705.5 |
| الوصف: | Background Not enough is known about predicting therapeutic response to serotonin-specific reuptake inhibitors, and specifically to fluoxetine. This exploratory study used psychological and biological markers for (retrospective) prediction of treatment-response to fluoxetine in depressed and/or anxious adolescents. Methods Forty-one consecutive adolescent outpatients with a primary diagnosis of severe affective and/or anxiety disorders were assessed and treated with an open-label 8-week trial of fluoxetine. Type D personality was assessed with the 14-item questionnaire, the DS14. In addition, TNFα, IL-6, and IL-1b were measured pre- and post-treatment. Results There was an elevation of Type D personality in patients, compared to the adolescent population rate. Post-treatment, 44% of patients were classified as non-responders; the relative risk of non-response for Type D personality patients was 2.8. Binary logistic regression predicting response vs. non-response showed a contribution of initial TNFα levels as well as Type D personality to non-response. Conclusions In this exploratory study, the most significant contributor to non-response was Type D personality. However, the measurement of Type D was not prospective, and thus may be confounded with psychiatric morbidity. The measurement of personality in psychiatric settings may contribute to the understanding of treatment response and have clinical utility. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2167-8359 |
| Relation: | https://peerj.com/articles/4240.pdf; https://peerj.com/articles/4240/; https://doaj.org/toc/2167-8359 |
| DOI: | 10.7717/peerj.4240 |
| URL الوصول: | https://doaj.org/article/07818ce2dba84e0fa378c160332067d1 |
| رقم الأكسشن: | edsdoj.07818ce2dba84e0fa378c160332067d1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21678359 |
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| DOI: | 10.7717/peerj.4240 |