دورية أكاديمية
The role of HR-HPV integration in the progression of premalignant lesions into different cancer types
| العنوان: | The role of HR-HPV integration in the progression of premalignant lesions into different cancer types |
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| المؤلفون: | Oscar Catalán-Castorena, Olga Lilia Garibay-Cerdenares, Berenice Illades-Aguiar, Hugo Alberto Rodríguez-Ruiz, Ma. Isabel Zubillaga-Guerrero, Marco Antonio Leyva-Vázquez, Sergio Encarnación-Guevara, Luz del Carmen Alarcón-Romero |
| المصدر: | Heliyon, Vol 10, Iss 15, Pp e34999- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | HR-HPV, Integration events, Cervical cancer, Head and neck cancer, Anal cancer, Penile cancer, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | High-risk human papillomavirus (HR-HPV) is associated with the development of different types of cancer, such as cervical, head and neck (including oral, laryngeal, and oropharyngeal), vulvar, vaginal, penile, and anal cancers. The progression of premalignant lesions to cancer depends on factors associated with the host cell and the different epithelia infected by HPV, such as basal cells of the flat epithelium and the cells of the squamocolumnar transformation zone (STZ) found in the uterine cervix and the anal canal, which is rich in heparan sulfate proteoglycans and integrin-like receptors. On the other hand, factors associated with the viral genotype, infection with multiple viruses, viral load, viral persistence, and type of integration determine the viral breakage pattern and the sites at which the virus integrates into the host cell genome (introns, exons, intergenic regions), inducing the loss of function of tumor suppressor genes and increasing oncogene expression. This review describes the role of viral integration and the molecular mechanisms induced by HR-HPV in different types of tissues. The purpose of this review is to identify the common factors associated with the role of integration events in the progression of premalignant lesions in different types of cancer. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844024110304; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2024.e34999 |
| URL الوصول: | https://doaj.org/article/07ae258d560243e38712832a2728eb94 |
| رقم الأكسشن: | edsdoj.07ae258d560243e38712832a2728eb94 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2024.e34999 |