دورية أكاديمية
أعرض في EDS

Diminished white matter integrity in patients with systemic lupus erythematosus

التفاصيل البيبلوغرافية
العنوان: Diminished white matter integrity in patients with systemic lupus erythematosus
المؤلفون: Tobias Schmidt-Wilcke, Patricia Cagnoli, Page Wang, Thomas Schultz, Anne Lotz, William J. Mccune, Pia C. Sundgren
المصدر: NeuroImage: Clinical, Vol 5, Iss C, Pp 291-297 (2014)
بيانات النشر: Elsevier, 2014.
سنة النشر: 2014
المجموعة: LCC:Computer applications to medicine. Medical informatics
LCC:Neurology. Diseases of the nervous system
مصطلحات موضوعية: Systemic lupus erythematosus, Diffusion tensor imaging, White matter, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429
الوصف: Purpose: Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease that can affect the central nervous system. Neuropsychiatric symptoms are found in 25–70% of patients. Using diffusion tensor imaging (DTI) various studies have reported changes in white matter integrity in SLE patients with neuropsychiatric symptoms (NPSLE patients). The purpose of this study was to investigate, if regional changes in white matter integrity can also be detected in SLE patients without neuropsychiatric symptoms (non-NPSLE patients). Methods: Applying DTI and tract based spatial statistics (TBSS) we investigated 19 NPSLE patients, 19 non-NPSLE and 18 healthy controls. Groups were matched for age and sex. Image pre-processing was performed using FSL, following the TBSS pipeline (eddy current correction, estimation of fractional anisotropy (FA), normalization, skeletonization of the group mean FA image). A general linear model with threshold-free cluster enhancement was used to assess significant differences between the three groups. Results: Statistical analyses revealed several regions of decreased prefrontal white matter integrity (decreased FA) in both groups of SLE patients. The changes found in the non-NPSLE patients (as compared to healthy controls) overlapped with those in the NPSLE patients, but were not as pronounced. Conclusions: Our data suggest that changes in regional white matter integrity, in terms of a decrease in FA, are present not only in NPSLE patients, but also in non-NPSLE patients, though to a lesser degree. We also demonstrate that the way statistical maps are corrected for multiple comparisons has a profound influence on whether alterations in white matter integrity in non-NPSLE patients are deemed significant.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2213-1582
Relation: http://www.sciencedirect.com/science/article/pii/S2213158214000916; https://doaj.org/toc/2213-1582
DOI: 10.1016/j.nicl.2014.07.001
URL الوصول: https://doaj.org/article/07c99708b625441aa3166077d9478d5b
رقم الأكسشن: edsdoj.07c99708b625441aa3166077d9478d5b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:22131582
DOI:10.1016/j.nicl.2014.07.001