دورية أكاديمية
Multimarker risk stratification approach and cardiovascular outcomes in patients with stable coronary artery disease undergoing elective percutaneous coronary intervention
العنوان: | Multimarker risk stratification approach and cardiovascular outcomes in patients with stable coronary artery disease undergoing elective percutaneous coronary intervention |
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المؤلفون: | Vimal Mehta, Rishi Sukhija, Pratishtha Mehra, Anuj Goyal, Jamal Yusuf, Bhawna Mahajan, V.K. Gupta, Sanjay Tyagi, Chandrasekar Palaniswamy, Wilbert S. Aronow |
المصدر: | Indian Heart Journal, Vol 68, Iss 1, Pp 57-62 (2016) |
بيانات النشر: | Elsevier, 2016. |
سنة النشر: | 2016 |
المجموعة: | LCC:Surgery LCC:Diseases of the circulatory (Cardiovascular) system |
مصطلحات موضوعية: | Biomarkers, Percutaneous coronary intervention, Periprocedural myocardial infarction, Major adverse cardiovascular event, Surgery, RD1-811, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
الوصف: | Aims: We studied the utility of multimarker risk stratification approach to predict cardiovascular outcomes in patients with stable coronary artery disease, undergoing elective percutaneous coronary intervention (PCI). Methods: We prospectively evaluated 302 consecutive patients with stable coronary artery disease and normal CPK-MB and cardiac troponin T levels, and who underwent elective PCI at our institution. The following cardiac biomarkers were measured before and between 12 and 24 h post-procedure: CK-MB, cardiac troponin T, hs-CRP, and NT-ProBNP. Patients were followed up for a minimum of 6 months. Results: Post-PCI, CPK-MB levels were elevated but below myocardial infarction (MI) range in 70 patients (23%), and in the MI range in 6 patients (2%). Troponin T levels were detectable but below the 99th percentile (microleak) in 32 patients (10.6%) and elevated above the 99th percentile (periprocedural MI) in 104 patients (34.4%). At 9 months’ follow-up, 1% died, 2% had stable angina, 10.3% had non-fatal MI, and 87.7% remained asymptomatic. There was no significant difference in clinical events among groups stratified by elevation of one biomarker or multiple biomarkers. Conclusion: Single or multiple biomarker strategy in patients with normal baseline biomarkers failed to predict major cardiac events after PCI over medium-term follow-up. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 0019-4832 |
Relation: | http://www.sciencedirect.com/science/article/pii/S0019483215002606; https://doaj.org/toc/0019-4832 |
DOI: | 10.1016/j.ihj.2015.06.034 |
URL الوصول: | https://doaj.org/article/e07d685ba0494cbe8daff303715c447a |
رقم الأكسشن: | edsdoj.07d685ba0494cbe8daff303715c447a |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 00194832 |
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DOI: | 10.1016/j.ihj.2015.06.034 |