دورية أكاديمية
Developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to Concanavalin A in rats
| العنوان: | Developmental exposure to low doses of dichlorodiphenyltrichloroethane impairs proliferative response of thymic lymphocytes to Concanavalin A in rats |
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| المؤلفون: | Nataliya V. Yaglova, Elina S. Tsomartova, Sergey S. Obernikhin, Marina Y. Ivanova, Elizaveta V. Chereshneva, Svetlana G. Muhamedova, Tatiana A. Lomanovskaya, Valentin V. Yaglov |
| المصدر: | Heliyon, Vol 6, Iss 3, Pp e03608- (2020) |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Thymus, Proliferative response, Concanavalin A, Development, Thymic lymphocytes, Endocrine disrupter, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | The aim of the research was to study formation of thymic lymphocytes proliferative response to T cell mitogen Concanavalin A in 7, 42, and 70 days-old male Wistar rats developmentally exposed to low doses of endocrine disruptor dichlorodiphenyltrichloroethane (2.90 ± 0.13 μg/kg body weight). The thymus of the exposed rats did not show morphological abnormalities. Exposure to the endocrine disrupter was found to alter age-dependent changes of thymic lymphocyte proliferative activity and attenuate proliferative response to Concanavalin A in puberty and adulthood. Insufficient response to mitogen was mediated by higher content of actively proliferating Ki-67-positive lymphoblasts compared to the control values. Insufficient proliferative response to mitogen in developmentally exposed to the endocrine disruptor rats may provide higher risk of impaired cellular immune reactions. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844020304539; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2020.e03608 |
| URL الوصول: | https://doaj.org/article/07e2daeb1b404ac4ac8e20bb9da239a5 |
| رقم الأكسشن: | edsdoj.07e2daeb1b404ac4ac8e20bb9da239a5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2020.e03608 |